ID   CASA2_CAMDR             Reviewed;         193 AA.
AC   O97944;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Alpha-S2-casein;
DE   Flags: Precursor;
GN   Name=CSN1S2;
OS   Camelus dromedarius (Dromedary) (Arabian camel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX   NCBI_TaxID=9838;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, PHOSPHORYLATION AT
RP   SER-23; SER-24; SER-25; SER-47; SER-68; SER-123; SER-125; SER-128 AND
RP   SER-136, AND MASS SPECTROMETRY.
RC   STRAIN=Somali; TISSUE=Udder;
RX   PubMed=9627840; DOI=10.1017/s0022029997002847;
RA   Kappeler S., Farah Z., Puhan Z.;
RT   "Sequence analysis of Camelus dromedarius milk caseins.";
RL   J. Dairy Res. 65:209-222(1998).
CC   -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- MASS SPECTROMETRY: Mass=21993; Method=MALDI; Note=with 9 phosphate
CC       groups.; Evidence={ECO:0000269|PubMed:9627840};
CC   -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR   EMBL; AJ012629; CAA10078.1; -; mRNA.
DR   RefSeq; NP_001290490.1; NM_001303561.1.
DR   AlphaFoldDB; O97944; -.
DR   SMR; O97944; -.
DR   iPTMnet; O97944; -.
DR   GeneID; 105090951; -.
DR   KEGG; cdk:105090951; -.
DR   OrthoDB; 1489083at2759; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR011175; Alpha-s2_casein.
DR   InterPro; IPR001588; Casein.
DR   PANTHER; PTHR16656; PTHR16656; 1.
DR   Pfam; PF00363; Casein; 1.
DR   PIRSF; PIRSF002371; Alpha-s2-casein; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Milk protein; Phosphoprotein; Secreted; Signal.
FT   SIGNAL          1..15
FT   CHAIN           16..193
FT                   /note="Alpha-S2-casein"
FT                   /id="PRO_0000004462"
FT   MOD_RES         23
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000305|PubMed:9627840"
FT   MOD_RES         24
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000305|PubMed:9627840"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000305|PubMed:9627840"
FT   MOD_RES         28
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         47
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000305|PubMed:9627840"
FT   MOD_RES         68
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000305|PubMed:9627840"
FT   MOD_RES         123
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000305|PubMed:9627840"
FT   MOD_RES         125
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000305|PubMed:9627840"
FT   MOD_RES         128
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000305|PubMed:9627840"
FT   MOD_RES         136
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000305|PubMed:9627840"
SQ   SEQUENCE   193 AA;  22964 MW;  2843256F8FD2ED13 CRC64;
     MKFFIFTCLL AVVLAKHEMD QGSSSEESIN VSQQKFKQVK KVAIHPSKED ICSTFCEEAV
     RNIKEVESAE VPTENKISQF YQKWKFLQYL QALHQGQIVM NPWDQGKTRA YPFIPTVNTE
     QLSISEESTE VPTEESTEVF TKKTELTEEE KDHQKFLNKI YQYYQTFLWP EYLKTVYQYQ
     KTMTPWNHIK RYF