ID   Y5547_DICDI             Reviewed;         335 AA.
AC   Q8MXL9; Q553B5;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=PA-phosphatase related-family protein DDB_G0275547;
GN   ORFNames=DDB_G0275547;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC       family. {ECO:0000305}.
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DR   EMBL; AAFI02000013; EAL69524.1; -; Genomic_DNA.
DR   RefSeq; XP_643505.1; XM_638413.1.
DR   AlphaFoldDB; Q8MXL9; -.
DR   STRING; 44689.DDB0232325; -.
DR   PaxDb; Q8MXL9; -.
DR   EnsemblProtists; EAL69524; EAL69524; DDB_G0275547.
DR   GeneID; 8620086; -.
DR   KEGG; ddi:DDB_G0275547; -.
DR   dictyBase; DDB_G0275547; -.
DR   eggNOG; KOG3030; Eukaryota.
DR   HOGENOM; CLU_757429_0_0_1; -.
DR   InParanoid; Q8MXL9; -.
DR   OMA; YMQFFPA; -.
DR   PhylomeDB; Q8MXL9; -.
DR   Reactome; R-DDI-1660661; Sphingolipid de novo biosynthesis.
DR   Reactome; R-DDI-2029485; Role of phospholipids in phagocytosis.
DR   Reactome; R-DDI-419408; Lysosphingolipid and LPA receptors.
DR   PRO; PR:Q8MXL9; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008195; F:phosphatidate phosphatase activity; IBA:GO_Central.
DR   GO; GO:0006644; P:phospholipid metabolic process; IEA:InterPro.
DR   InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR   InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR   InterPro; IPR043216; PA_PP_rel.
DR   PANTHER; PTHR10165; PTHR10165; 1.
DR   Pfam; PF01569; PAP2; 1.
DR   SMART; SM00014; acidPPc; 1.
DR   SUPFAM; SSF48317; SSF48317; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..335
FT                   /note="PA-phosphatase related-family protein DDB_G0275547"
FT                   /id="PRO_0000367485"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   335 AA;  37750 MW;  BD6854EFD3719FCA CRC64;
     MDRNFLNESN NSTNNRNKYV IYDEEESKPL FYNYDFRKKN KMVMYLFDWM MVVILLIVGG
     ILFLKVTVRG RLFTLDDESI SYPKLPELVP MHVLIPVIIA LPLAIIIVVS LIVKRDCHDF
     HHAILGLAQS LALTLLLTGS FKCFIGGLRP NFLEVCDPTP ASIAAGNPPV GFSKIYYDRS
     ICSADDSIVN DALSAYPSGH SSITAASFGF LALFIHAKFK IFDNRGHIFL YVIVSGCIIG
     AGLIGISRVA DYRHTFLNVL AGWSIGLIIA LSCYRLNYSS LFGRDNHVSI HSHWLTYWNH
     HDNLNNNNNN IKNNFDLEKN CNQSPNNIAL DELNK