CASA2_CAPHI
ID CASA2_CAPHI Reviewed; 223 AA.
AC P33049; Q9GK07; Q9MYU6; Q9MYU7; Q9TTQ7;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Alpha-S2-casein;
DE Short=Alpha-S2-CN;
DE Flags: Precursor;
GN Name=CSN1S2;
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8462880; DOI=10.1016/0378-1119(93)90336-2;
RA Bouniol C.;
RT "Sequence of the goat alpha s2-casein-encoding cDNA.";
RL Gene 125:235-236(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE, AND VARIANT ALLELE B LYS-79.
RA Bouniol C., Brignon G., Mahe M.-F., Printz C.;
RT "Characterization of goat allelic alpha-s2-caseins A and B: further
RT evidence of the phosphorylation code of caseins.";
RL Protein Seq. Data Anal. 5:213-218(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALLELE C ILE-182.
RX PubMed=7943951; DOI=10.1111/j.1365-2052.1994.tb00106.x;
RA Bouniol C., Brignon G., Mahe M.-F., Printz C.;
RT "Biochemical and genetic analysis of variant C of caprine alpha s2-casein
RT (Capra hircus).";
RL Anim. Genet. 25:173-177(1994).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALLELE F ILE-22.
RX PubMed=11683712; DOI=10.1046/j.1365-2052.2001.00786.x;
RA Ramunno L., Cosenza G., Pappalardo M., Longobardi E., Gallo D., Pastore N.,
RA Di Gregorio P., Rando A.;
RT "Characterization of two new alleles at the goat CSN1S2 locus.";
RL Anim. Genet. 32:264-268(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANTS ILE-182 AND ARG-208.
RX PubMed=11736814; DOI=10.1046/j.1365-2052.2001.0781c.x;
RA Lagonigro R., Pietrola E., D'Andrea M., Veltri C., Pilla F.;
RT "Molecular genetic characterization of the goat s2-casein E allele.";
RL Anim. Genet. 32:391-393(2001).
CC -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC phosphate.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC -!- POLYMORPHISM: The frequencies of the A, B and C alleles is estimated to
CC be 0.85, 0.04 and 0.11 in the French dairy breeds 'Alpine' and
CC 'Saanen'.
CC -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR EMBL; X65160; CAA46278.1; -; mRNA.
DR EMBL; S74171; AAB32166.1; -; Genomic_DNA.
DR EMBL; AJ249995; CAB59920.1; -; mRNA.
DR EMBL; AJ289715; CAB94235.1; -; mRNA.
DR EMBL; AJ289716; CAB94236.1; -; mRNA.
DR EMBL; AJ297310; CAC21704.2; -; Genomic_DNA.
DR EMBL; AJ242526; CAC21704.2; JOINED; Genomic_DNA.
DR EMBL; AJ242528; CAC21704.2; JOINED; Genomic_DNA.
DR EMBL; AJ242527; CAC21704.2; JOINED; Genomic_DNA.
DR EMBL; AJ242533; CAC21704.2; JOINED; Genomic_DNA.
DR EMBL; AJ297311; CAC21704.2; JOINED; Genomic_DNA.
DR EMBL; AJ297313; CAC21704.2; JOINED; Genomic_DNA.
DR EMBL; AJ297315; CAC21704.2; JOINED; Genomic_DNA.
DR EMBL; AJ297316; CAC21704.2; JOINED; Genomic_DNA.
DR EMBL; AJ297314; CAC21704.2; JOINED; Genomic_DNA.
DR EMBL; AJ297312; CAC21704.2; JOINED; Genomic_DNA.
DR EMBL; AJ242728; CAC21704.2; JOINED; Genomic_DNA.
DR PIR; I46995; I46995.
DR PIR; S33881; JN0547.
DR RefSeq; NP_001272514.1; NM_001285585.1.
DR AlphaFoldDB; P33049; -.
DR SMR; P33049; -.
DR Allergome; 1242; Cap h 8.
DR Allergome; 2967; Cap h 10.
DR GeneID; 100861229; -.
DR KEGG; chx:100861229; -.
DR CTD; 100327035; -.
DR OrthoDB; 1489083at2759; -.
DR Proteomes; UP000291000; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR011175; Alpha-s2_casein.
DR InterPro; IPR001588; Casein.
DR InterPro; IPR031305; Casein_CS.
DR PANTHER; PTHR16656; PTHR16656; 1.
DR Pfam; PF00363; Casein; 1.
DR PIRSF; PIRSF002371; Alpha-s2-casein; 1.
DR PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE 2: Evidence at transcript level;
KW Milk protein; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000250"
FT CHAIN 16..223
FT /note="Alpha-S2-casein"
FT /id="PRO_0000004463"
FT REPEAT 77..141
FT REPEAT 159..223
FT MOD_RES 23
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 73
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 74
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 77
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 145
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O97944"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O97944"
FT MOD_RES 151
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O97944"
FT MOD_RES 159
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT VARIANT 22
FT /note="V -> I (in allele F)"
FT /evidence="ECO:0000269|PubMed:11683712"
FT VARIANT 79
FT /note="E -> K (in allele B)"
FT /evidence="ECO:0000269|Ref.2"
FT VARIANT 161
FT /note="E -> K (in allele 0)"
FT VARIANT 182
FT /note="K -> I (in allele C and allele E)"
FT /evidence="ECO:0000269|PubMed:11736814,
FT ECO:0000269|PubMed:7943951"
FT VARIANT 208
FT /note="P -> R (in allele E)"
FT /evidence="ECO:0000269|PubMed:11736814"
SQ SEQUENCE 223 AA; 26389 MW; 187DEF42FD688291 CRC64;
MKFFIFTCLL AVALAKHKME HVSSSEEPIN IFQEIYKQEK NMAIHPRKEK LCTTSCEEVV
RNANEEEYSI RSSSEESAEV APEEIKITVD DKHYQKALNE INQFYQKFPQ YLQYPYQGPI
VLNPWDQVKR NAGPFTPTVN REQLSTSEEN SKKTIDMEST EVFTKKTKLT EEEKNRLNFL
KKISQYYQKF AWPQYLKTVD QHQKAMKPWT QPKTNAIPYV RYL
