ID   CASA2_CAVPO             Reviewed;         223 AA.
AC   P04655;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Alpha-S2-casein;
DE   AltName: Full=Casein-A;
DE   Flags: Precursor;
GN   Name=CSN1S2;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6546370; DOI=10.1111/j.1432-1033.1984.tb07954.x;
RA   Hall L., Laird J.E., Pascall J.C., Craig R.K.;
RT   "Guinea-pig casein A cDNA. Nucleotide sequence analysis and comparison of
RT   the deduced protein sequence with that of bovine alpha s2 casein.";
RL   Eur. J. Biochem. 138:585-589(1984).
CC   -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR   EMBL; X00374; CAA25110.1; -; mRNA.
DR   PIR; A27237; A27237.
DR   RefSeq; NP_001166365.1; NM_001172894.1.
DR   AlphaFoldDB; P04655; -.
DR   SMR; P04655; -.
DR   STRING; 10141.ENSCPOP00000010495; -.
DR   PRIDE; P04655; -.
DR   GeneID; 100379582; -.
DR   KEGG; cpoc:100379582; -.
DR   CTD; 100327035; -.
DR   eggNOG; ENOG502TDWX; Eukaryota.
DR   InParanoid; P04655; -.
DR   OrthoDB; 1489083at2759; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR011175; Alpha-s2_casein.
DR   InterPro; IPR001588; Casein.
DR   InterPro; IPR031305; Casein_CS.
DR   PANTHER; PTHR16656; PTHR16656; 1.
DR   Pfam; PF00363; Casein; 1.
DR   PIRSF; PIRSF002371; Alpha-s2-casein; 1.
DR   PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..223
FT                   /note="Alpha-S2-casein"
FT                   /id="PRO_0000004465"
FT   REPEAT          76..128
FT   REPEAT          129..223
FT   MOD_RES         23
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         24
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         28
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         46
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         71
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         72
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         73
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         132
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O97944"
FT   MOD_RES         147
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O97944"
FT   MOD_RES         155
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
SQ   SEQUENCE   223 AA;  25837 MW;  F71349089330337D CRC64;
     MKLFIFTCLL AVALAKHKSE QQSSSEESVS ISQEKFKDKN MDTISSEETI CASLCKEATK
     NTPKMAFFSR SSSEEFADIH RENKKDQLYQ KWMVPQYNPD FYQRPVVMSP WNQIYTRPYP
     IVLPTLGKEQ ISTIEDILKK TTAVESSSSS STEKSTDVFI KKTKMDEVQK LIQSLLNIIH
     EYSQKAFWSQ TLEDVDQYLK FVMPWNHYNT NADQVDASQE RQA