ID   Y555_METJA              Reviewed;         350 AA.
AC   Q57975;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Putative aminopeptidase MJ0555;
DE            EC=3.4.11.-;
GN   OrderedLocusNames=MJ0555;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250};
CC       Note=Binds 2 divalent metal cations per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the peptidase M42 family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98546.1; -; Genomic_DNA.
DR   PIR; C64369; C64369.
DR   RefSeq; WP_010870059.1; NC_000909.1.
DR   AlphaFoldDB; Q57975; -.
DR   SMR; Q57975; -.
DR   STRING; 243232.MJ_0555; -.
DR   EnsemblBacteria; AAB98546; AAB98546; MJ_0555.
DR   GeneID; 1451420; -.
DR   KEGG; mja:MJ_0555; -.
DR   eggNOG; arCOG01518; Archaea.
DR   HOGENOM; CLU_047249_1_0_2; -.
DR   InParanoid; Q57975; -.
DR   OMA; FGWPAIH; -.
DR   OrthoDB; 27966at2157; -.
DR   PhylomeDB; Q57975; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.30.40; -; 1.
DR   InterPro; IPR008007; Peptidase_M42.
DR   InterPro; IPR023367; Peptidase_M42_dom2.
DR   Pfam; PF05343; Peptidase_M42; 1.
DR   PIRSF; PIRSF001123; PepA_GA; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase; Hydrolase; Metal-binding; Metalloprotease; Protease;
KW   Reference proteome.
FT   CHAIN           1..350
FT                   /note="Putative aminopeptidase MJ0555"
FT                   /id="PRO_0000071660"
FT   ACT_SITE        207
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         62
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         175
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         175
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         208
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         230
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         321
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   350 AA;  38622 MW;  9D4942EF5528955B CRC64;
     MSVVEYLKKL SKLHGISGRE DSVREFMKKE LEKYCDSVEI DNFGNLIAKR GNKGKKIMIA
     AHMDEIGLMV KYIDDNGFLK FTKIGGIYDP TILNQKVVVH GSKGDLIGVL GSKPPHRMKE
     EEKTKIIKYE DMFIDIGAES REEAIEMGVN IGTWVSFLSE VYDLGKNRLT GKAFDDRVGC
     AVLLEVMKRL SEEDIDCQVY AVGTVQEEVG LKGARVSAFK INPDVAIALD VTIAGDHPGI
     KKEDAPVDLG KGPVVGIVDA SGRGLIAHPK VLDMIKAVSE KYKIDVQWEV GEGGTTDATA
     IHLTREGIPT GVISVPARYI HTPVEVIDKR DLEKTVELVY NCIKEVNNFF