ID   CASA2_PIG               Reviewed;         235 AA.
AC   P39036;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Alpha-S2-casein;
DE   Flags: Precursor;
GN   Name=CSN1S2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=1503276;
RA   Alexander L.J., Das Gupta N.A., Beattie C.W.;
RT   "The sequence of porcine alpha s2-casein cDNA.";
RL   Anim. Genet. 23:365-367(1992).
CC   -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X54975; CAA38719.1; -; mRNA.
DR   RefSeq; NP_001004030.1; NM_001004030.1.
DR   RefSeq; XP_005656642.1; XM_005656585.1.
DR   AlphaFoldDB; P39036; -.
DR   SMR; P39036; -.
DR   STRING; 9823.ENSSSCP00000009878; -.
DR   PaxDb; P39036; -.
DR   PeptideAtlas; P39036; -.
DR   PRIDE; P39036; -.
DR   GeneID; 445515; -.
DR   KEGG; ssc:445515; -.
DR   CTD; 100327035; -.
DR   eggNOG; ENOG502TDWX; Eukaryota.
DR   HOGENOM; CLU_121717_0_0_1; -.
DR   InParanoid; P39036; -.
DR   OrthoDB; 1056951at2759; -.
DR   TreeFam; TF339561; -.
DR   ChiTaRS; CSN1S2; pig.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; P39036; SS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR   GO; GO:0035375; F:zymogen binding; IBA:GO_Central.
DR   InterPro; IPR011175; Alpha-s2_casein.
DR   InterPro; IPR001588; Casein.
DR   InterPro; IPR031305; Casein_CS.
DR   PANTHER; PTHR16656; PTHR16656; 1.
DR   Pfam; PF00363; Casein; 1.
DR   PIRSF; PIRSF002371; Alpha-s2-casein; 1.
DR   PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..235
FT                   /note="Alpha-S2-casein"
FT                   /id="PRO_0000004464"
FT   REGION          144..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..162
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         23
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         24
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         28
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         47
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         72
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         73
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         74
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         77
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         147
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O97944"
FT   MOD_RES         149
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O97944"
FT   MOD_RES         168
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
SQ   SEQUENCE   235 AA;  27570 MW;  C903B760D184C14C CRC64;
     MKFFIFTCLL AVAFAKHEME HVSSSEESIN ISQEKYKQEK NVINHPSKED ICATSCEEAV
     RNIKEVGYAS SSSSEESVDI PAENVKVTVE DKHYLKQLEK ISQFYQKFPQ YLQALYQAQI
     VMNPWDQTKT SAYPFIPTVI QSGEELSTSE EPVSSSQEEN TKTVDMESME EFTKKTELTE
     EEKNRIKFLN KIKQYYQKFT WPQYIKTVHQ KQKAMKPWNH IKTNSYQIIP NLRYF