ID   CASA2_RABIT             Reviewed;         182 AA.
AC   P50419;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Alpha-S2-casein;
DE   AltName: Full=Alpha-S2B-casein;
DE   Flags: Precursor;
GN   Name=CSN1S2;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Mammary gland;
RX   PubMed=8280077; DOI=10.1042/bj2960777;
RA   Dawson S.P., Wilde C.J., Tighe P.J., Mayer R.J.;
RT   "Characterization of two novel casein transcripts in rabbit mammary
RT   gland.";
RL   Biochem. J. 296:777-784(1993).
CC   -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR   EMBL; X76909; CAA54231.1; -; mRNA.
DR   PIR; S39776; S39776.
DR   RefSeq; NP_001075870.1; NM_001082401.1.
DR   AlphaFoldDB; P50419; -.
DR   SMR; P50419; -.
DR   STRING; 9986.ENSOCUP00000024897; -.
DR   Allergome; 2149; Ory c 8.
DR   PRIDE; P50419; -.
DR   GeneID; 100009288; -.
DR   KEGG; ocu:100009288; -.
DR   CTD; 100327035; -.
DR   eggNOG; ENOG502TDWX; Eukaryota.
DR   HOGENOM; CLU_121717_0_0_1; -.
DR   InParanoid; P50419; -.
DR   OMA; VMNPWDQ; -.
DR   OrthoDB; 1489083at2759; -.
DR   TreeFam; TF339561; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR011175; Alpha-s2_casein.
DR   InterPro; IPR001588; Casein.
DR   InterPro; IPR031305; Casein_CS.
DR   PANTHER; PTHR16656; PTHR16656; 1.
DR   Pfam; PF00363; Casein; 1.
DR   PIRSF; PIRSF002371; Alpha-s2-casein; 1.
DR   PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..182
FT                   /note="Alpha-S2-casein"
FT                   /id="PRO_0000004456"
FT   MOD_RES         22
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         23
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
FT   MOD_RES         24
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02663"
SQ   SEQUENCE   182 AA;  21597 MW;  F2432C2DA45550FC CRC64;
     MKFFIFTCLL AVALAKPKIE QSSSEETIAV SQEVSPNLEN ICSTACEEPI KNINEVEYVE
     VPTEIKDQEF YQKVNLLQYL QALYQYPTVM DPWTRAETKA IPFIRTMQYK QEKDATKHTS
     QKTELTEEEK AFLKYLDEMK QYYQKFVFPQ YLKNAHHFQK TMNPWNHVKT IIYQSVPTLR
     YL