CASA2_SHEEP
ID CASA2_SHEEP Reviewed; 223 AA.
AC P04654;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Alpha-S2-casein;
DE Flags: Precursor;
GN Name=CSN1S2;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3002499; DOI=10.1016/s0300-9084(85)80299-6;
RA Boisnard M., Petrissant G.;
RT "Complete sequence of ovine alpha s2-casein messenger RNA.";
RL Biochimie 67:1043-1051(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1935959; DOI=10.1111/j.1432-1033.1991.tb16324.x;
RA Boisnard M., Hue D., Bouniol C., Mercier J.-C., Gaye P.;
RT "Multiple mRNA species code for two non-allelic forms of ovine alpha s2-
RT casein.";
RL Eur. J. Biochem. 201:633-641(1991).
CC -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC phosphate.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR EMBL; X03238; CAA26983.1; -; mRNA.
DR PIR; A25070; KASHS2.
DR RefSeq; NP_001009363.1; NM_001009363.1.
DR AlphaFoldDB; P04654; -.
DR SMR; P04654; -.
DR STRING; 9940.ENSOARP00000011473; -.
DR Allergome; 1241; Ovi a 8.
DR Allergome; 2963; Ovi a 10.
DR PRIDE; P04654; -.
DR GeneID; 443383; -.
DR KEGG; oas:443383; -.
DR CTD; 100327035; -.
DR eggNOG; ENOG502TDWX; Eukaryota.
DR OrthoDB; 1489083at2759; -.
DR Proteomes; UP000002356; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR011175; Alpha-s2_casein.
DR InterPro; IPR001588; Casein.
DR InterPro; IPR031305; Casein_CS.
DR PANTHER; PTHR16656; PTHR16656; 1.
DR Pfam; PF00363; Casein; 1.
DR PIRSF; PIRSF002371; Alpha-s2-casein; 1.
DR PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE 2: Evidence at transcript level;
KW Milk protein; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000250"
FT CHAIN 16..223
FT /note="Alpha-S2-casein"
FT /id="PRO_0000004469"
FT REPEAT 77..141
FT REPEAT 159..223
FT MOD_RES 23
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 73
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 74
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 77
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT MOD_RES 145
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O97944"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O97944"
FT MOD_RES 151
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O97944"
FT MOD_RES 159
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02663"
FT VARIANT 64
FT /note="D -> N"
FT CONFLICT 94
FT /note="Y -> T (in Ref. 2; no nucleotide entry)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 223 AA; 26332 MW; 67212935E27426D7 CRC64;
MKFFIFTCLL AVALAKHKME HVSSSEEPIN ISQEIYKQEK NMAIHPRKEK LCTTSCEEVV
RNADEEEYSI RSSSEESAEV APEEVKITVD DKHYQKALNE INQFYQKFPQ YLQYLYQGPI
VLNPWDQVKR NAGPFTPTVN REQLSTSEEN SKKTIDMEST EVFTKKTKLT EEEKNRLNFL
KKISQYYQKF AWPQYLKTVD QHQKAMKPWT QPKTNAIPYV RYL
