ID   CASB_BUBBU              Reviewed;         224 AA.
AC   Q9TSI0; O62824; Q2PMW0;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Beta-casein;
DE   Flags: Precursor;
GN   Name=CSN2;
OS   Bubalus bubalis (Domestic water buffalo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bubalus.
OX   NCBI_TaxID=89462;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary gland;
RA   Klotz A., Krause I., Einspanier R.;
RT   "Isolation of mRNA from buffalo milk.";
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary gland;
RA   Das P., Garg L.C.;
RT   "cDNA cloning and sequencing of beta-casein gene in B. bubalis.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary gland;
RA   Mishra B.P., Mukesh M., Kataria R.S., Kumar V., Pandey D., Ahlawat S.P.S.;
RT   "Sequence analysis of beta-casein gene of Indian riverine buffalo (bubalus
RT   bubalis).";
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary gland;
RA   Bhattacharya T.K., Kumar P., Sharma A.;
RT   "Characterization of buffalo beta-casein gene.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Important role in determination of the surface properties of
CC       the casein micelles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the beta-casein family. {ECO:0000305}.
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DR   EMBL; AJ005165; CAA06408.1; -; mRNA.
DR   EMBL; AJ005432; CAA06535.1; -; mRNA.
DR   EMBL; DQ317447; ABC47037.1; -; mRNA.
DR   EMBL; DQ631829; ABG02276.1; -; mRNA.
DR   AlphaFoldDB; Q9TSI0; -.
DR   Allergome; 1259; Bub b 8.
DR   PRIDE; Q9TSI0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001588; Casein.
DR   InterPro; IPR016345; Casein_beta.
DR   InterPro; IPR031305; Casein_CS.
DR   PANTHER; PTHR11500; PTHR11500; 1.
DR   Pfam; PF00363; Casein; 1.
DR   PIRSF; PIRSF002372; Beta-casein; 1.
DR   PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..224
FT                   /note="Beta-casein"
FT                   /id="PRO_0000004471"
FT   MOD_RES         30
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   MOD_RES         32
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   MOD_RES         33
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   MOD_RES         34
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   CONFLICT        117
FT                   /note="M -> T (in Ref. 2; CAA06535)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   224 AA;  25106 MW;  14FD3687DD17C5A9 CRC64;
     MKVLILACLV ALALARELEE LNVPGEIVES LSSSEESITH INKKIEKFQS EEQQQMEDEL
     QDKIHPFAQT QSLVYPFPGP IPKSLPQNIP PLTQTPVVVP PFLQPEIMGV SKVKEAMAPK
     HKEMPFPKYP VEPFTESQSL TLTDVENLHL PLPLLQSWMH QPPQPLPPTV MFPPQSVLSL
     SQSKVLPVPQ KAVPYPQRDM PIQAFLLYQE PVLGPVRGPF PIIV