ID   CASB_CAPHI              Reviewed;         222 AA.
AC   P33048;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Beta-casein;
DE   Flags: Precursor;
GN   Name=CSN2;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Saanen; TISSUE=Blood;
RX   PubMed=1446822; DOI=10.1016/0378-1119(92)90129-d;
RA   Roberts B., Ditullio P., Vitale J., Hehir K., Gordon K.;
RT   "Cloning of the goat beta-casein-encoding gene and expression in transgenic
RT   mice.";
RL   Gene 121:255-262(1992).
CC   -!- FUNCTION: Important role in determination of the surface properties of
CC       the casein micelles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the beta-casein family. {ECO:0000305}.
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DR   EMBL; M90561; AAA30906.1; -; Genomic_DNA.
DR   EMBL; M90556; AAA30906.1; JOINED; Genomic_DNA.
DR   EMBL; M90557; AAA30906.1; JOINED; Genomic_DNA.
DR   EMBL; M90558; AAA30906.1; JOINED; Genomic_DNA.
DR   EMBL; M90560; AAA30906.1; JOINED; Genomic_DNA.
DR   PIR; JC1384; JC1384.
DR   AlphaFoldDB; P33048; -.
DR   SMR; P33048; -.
DR   Allergome; 1242; Cap h 8.
DR   Allergome; 2968; Cap h 11.
DR   iPTMnet; P33048; -.
DR   PRIDE; P33048; -.
DR   Proteomes; UP000291000; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001588; Casein.
DR   InterPro; IPR016345; Casein_beta.
DR   PANTHER; PTHR11500; PTHR11500; 1.
DR   Pfam; PF00363; Casein; 1.
DR   PIRSF; PIRSF002372; Beta-casein; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..222
FT                   /note="Beta-casein"
FT                   /id="PRO_0000004473"
FT   MOD_RES         27
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GKK3"
FT   MOD_RES         30
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   MOD_RES         32
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   MOD_RES         33
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   MOD_RES         34
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
SQ   SEQUENCE   222 AA;  24865 MW;  96AE17746A01CD05 CRC64;
     MKVLILACLV ALAIAREQEE LNVVGETVES LSSSEESITH INKKIEKFQS EEQQQTEDEL
     QDKIHPFAQA QSLVYPFTGP IPNSLPQNIL PLTQTPVVVP PFLQPEIMGV PKVKETMVPK
     HKEMPFPKYP VEPFTESQSL TLTDVEKLHL PLPLVQSWMH QPPQPLSPTV MFPPQSVLSL
     SQPKVLPVPQ KAVPQRDMPI QAFLLYQEPV LGPVRGPFPI LV