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Y5631_BACCX
ID   Y5631_BACCX             Reviewed;         295 AA.
AC   R8NBR0;
DT   10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2013, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Probable CBASS effector molecule IK1_05631 {ECO:0000305|PubMed:31533127};
GN   ORFNames=IK1_05631 {ECO:0000312|EMBL:EOP43921.1};
OS   Bacillus cereus (strain VD146).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1053236;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VD146;
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Feldgarden M., Van der Auwera G.A., Mahillon J., Duprez V., Timmery S.,
RA   Mattelet C., Dierick K., Sun M., Yu Z., Zhu L., Hu X., Shank E.B.,
RA   Swiecicka I., Hansen B.M., Andrup L., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The genome sequence of Bacillus cereus VD146.";
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   ANTIVIRAL DEFENSE, NOMENCLATURE, AND OPERON STRUCTURE.
RC   STRAIN=VD146;
RX   PubMed=31533127; DOI=10.1038/s41586-019-1605-5;
RA   Cohen D., Melamed S., Millman A., Shulman G., Oppenheimer-Shaanan Y.,
RA   Kacen A., Doron S., Amitai G., Sorek R.;
RT   "Cyclic GMP-AMP signalling protects bacteria against viral infection.";
RL   Nature 574:691-695(2019).
RN   [3]
RP   CLASSIFICATION AND NOMENCLATURE.
RX   PubMed=32839535; DOI=10.1038/s41564-020-0777-y;
RA   Millman A., Melamed S., Amitai G., Sorek R.;
RT   "Diversity and classification of cyclic-oligonucleotide-based anti-phage
RT   signalling systems.";
RL   Nat. Microbiol. 5:1608-1615(2020).
CC   -!- FUNCTION: CBASS (cyclic oligonucleotide-based antiphage signaling
CC       system) provides immunity against bacteriophage. The CD-NTase protein
CC       synthesizes cyclic nucleotides in response to infection; these serve as
CC       specific second messenger signals. The signals activate a diverse range
CC       of effectors, leading to bacterial cell death and thus abortive phage
CC       infection. A type I-B CBASS system (PubMed:32839535).
CC       {ECO:0000269|PubMed:31533127, ECO:0000303|PubMed:32839535}.
CC   -!- FUNCTION: Protects B.subtilis against phage infection. When IK1_05630
CC       and IK1_05631 are introduced in B.subtilis BEST7003 there is 1000-fold
CC       protection against phage SBSphiC. Both genes are required for
CC       protection. Activation leads to bacterial cell lysis and death, which
CC       occurs before the phage has finished its replication cycle, thus
CC       protecting non-infected bacteria by aborting the phage infection and
CC       preventing its propagation. {ECO:0000269|PubMed:31533127}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Part of the CBASS operon consisting of cdnD-IK1_05631.
CC       {ECO:0000305|PubMed:31533127}.
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DR   EMBL; AHFE01000034; EOP43921.1; -; Genomic_DNA.
DR   RefSeq; WP_016119573.1; NZ_KB976676.1.
DR   AlphaFoldDB; R8NBR0; -.
DR   EnsemblBacteria; EOP43921; EOP43921; IK1_05631.
DR   PATRIC; fig|1053236.3.peg.1318; -.
DR   HOGENOM; CLU_077101_0_0_9; -.
DR   Proteomes; UP000014020; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antiviral defense; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..295
FT                   /note="Probable CBASS effector molecule IK1_05631"
FT                   /id="PRO_0000451861"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   295 AA;  34347 MW;  1F3D66E583DE442C CRC64;
     MLEKQNSEEN IELLRAMRYC YNKSKIFYAV RISISILIPI LSISIYLFNR GSTGTSNTGV
     WFSVIGSIWL LIAYQIEKLE GGYIEKGAKI QEKFDINLFN IRWNNVLVGN QISPEDIRDF
     SSKFKGDEEK LKNWYGGLSS KHFYVNVILA QRSNLMWAIS LKRNFSILLF TVSVLYLFLT
     IAFGFFVNMS MQEYIIKILL PSMSILIYGF KTSDELKKQS NKLEALGNSI ISKFDTGNLS
     EINASACREY QDAIFVYNRI RSILIPEWLY WLRQQKDDEK MIQINIRLTK KSNLF
 
 
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