ID   Y563_MYCLE              Reviewed;         298 AA.
AC   Q9CCP0;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Nucleotide-binding protein ML0563 {ECO:0000255|HAMAP-Rule:MF_00636};
GN   OrderedLocusNames=ML0563;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Displays ATPase and GTPase activities. {ECO:0000255|HAMAP-
CC       Rule:MF_00636}.
CC   -!- SIMILARITY: Belongs to the RapZ-like family. {ECO:0000255|HAMAP-
CC       Rule:MF_00636}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL583918; CAC30071.1; -; Genomic_DNA.
DR   PIR; C86979; C86979.
DR   RefSeq; NP_301477.1; NC_002677.1.
DR   RefSeq; WP_010907801.1; NC_002677.1.
DR   AlphaFoldDB; Q9CCP0; -.
DR   SMR; Q9CCP0; -.
DR   STRING; 272631.ML0563; -.
DR   EnsemblBacteria; CAC30071; CAC30071; CAC30071.
DR   KEGG; mle:ML0563; -.
DR   PATRIC; fig|272631.5.peg.974; -.
DR   Leproma; ML0563; -.
DR   eggNOG; COG1660; Bacteria.
DR   HOGENOM; CLU_059558_0_0_11; -.
DR   OMA; TVMSFGF; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00636; RapZ_like; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005337; RapZ-like.
DR   PANTHER; PTHR30448; PTHR30448; 1.
DR   Pfam; PF03668; ATP_bind_2; 1.
DR   PIRSF; PIRSF005052; P-loopkin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..298
FT                   /note="Nucleotide-binding protein ML0563"
FT                   /id="PRO_0000107730"
FT   BINDING         21..28
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00636"
FT   BINDING         72..75
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00636"
SQ   SEQUENCE   298 AA;  32607 MW;  4E4E364E92F20D96 CRC64;
     MSGNNHPGDA SAEIDVVLVT GLSGAGRGTA AKVLEDLGWY VADNLPPQLI TWMVDFGLAA
     GSRITQLAVV MDVRSRGFTG DLDSVRRELA TRNIIPRVVF MEASDDMLVR RYEQNRRSHP
     LQGEQTLAEG IAAERRMLAP VRATADLIID TSALSVPGLR ESIERAFGGD ASATTSVTVE
     SFGFKYGLPM DADIVMDVRF LPNPHWVDEL RSLTGQHSAV RDYVLGQPGA AEFLRTYRRL
     LSLVVDGYRR EGKRYMTVAI GCTGGKHRSV AIAEALMGLL QSDLQLSVRV LHRDLGRE