CASB_MOUSE
ID CASB_MOUSE Reviewed; 231 AA.
AC P10598; Q543D9; Q8VCT6; Q8VCU8; Q91VI5; Q922Y5; Q9D1U6; Q9D1U7;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Beta-casein;
DE Flags: Precursor;
GN Name=Csn2; Synonyms=Csnb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3774558; DOI=10.1093/nar/14.20.8224;
RA Yoshimura M., Banerjee M.R., Oka T.;
RT "Nucleotide sequence of a cDNA encoding mouse beta casein.";
RL Nucleic Acids Res. 14:8224-8224(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=2673924; DOI=10.1016/0378-1119(89)90229-1;
RA Yoshimura M., Oka T.;
RT "Isolation and structural analysis of the mouse beta-casein gene.";
RL Gene 78:267-275(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C3H/HeN; TISSUE=Liver;
RX PubMed=2187188; DOI=10.1073/pnas.87.10.3670;
RA Yoshimura M., Oka T.;
RT "Transfection of beta-casein chimeric gene and hormonal induction of its
RT expression in primary murine mammary epithelial cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:3670-3674(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Important role in determination of the surface properties of
CC the casein micelles.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC -!- SIMILARITY: Belongs to the beta-casein family. {ECO:0000305}.
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DR EMBL; X04490; CAA28178.1; -; mRNA.
DR EMBL; X13484; CAA31840.1; -; Genomic_DNA.
DR EMBL; AK021324; BAB32374.1; -; mRNA.
DR EMBL; AK021328; BAB32375.1; -; mRNA.
DR EMBL; AK052803; BAC35152.1; -; mRNA.
DR EMBL; AK052805; BAC35153.1; -; mRNA.
DR EMBL; AK085694; BAC39508.1; -; mRNA.
DR EMBL; AK085729; BAC39522.1; -; mRNA.
DR EMBL; AK142616; BAE25131.1; -; mRNA.
DR EMBL; AK142620; BAE25133.1; -; mRNA.
DR EMBL; AK142635; BAE25141.1; -; mRNA.
DR EMBL; AK164747; BAE37898.1; -; mRNA.
DR EMBL; AK164791; BAE37917.1; -; mRNA.
DR EMBL; AK164792; BAE37918.1; -; mRNA.
DR EMBL; AK164793; BAE37919.1; -; mRNA.
DR EMBL; AK164794; BAE37920.1; -; mRNA.
DR EMBL; BC013332; AAH13332.1; -; mRNA.
DR EMBL; BC019114; AAH19114.1; -; mRNA.
DR EMBL; BC019189; AAH19189.1; -; mRNA.
DR EMBL; BC021153; AAH21153.1; -; mRNA.
DR CCDS; CCDS39131.1; -.
DR PIR; JU0061; JU0061.
DR RefSeq; NP_001272949.1; NM_001286020.1.
DR RefSeq; NP_001272950.1; NM_001286021.1.
DR RefSeq; NP_001272952.1; NM_001286023.1.
DR RefSeq; NP_034102.1; NM_009972.2.
DR AlphaFoldDB; P10598; -.
DR BioGRID; 198938; 3.
DR STRING; 10090.ENSMUSP00000080976; -.
DR PhosphoSitePlus; P10598; -.
DR PaxDb; P10598; -.
DR PeptideAtlas; P10598; -.
DR PRIDE; P10598; -.
DR ProteomicsDB; 265548; -.
DR Antibodypedia; 24273; 219 antibodies from 24 providers.
DR DNASU; 12991; -.
DR Ensembl; ENSMUST00000197422; ENSMUSP00000143341; ENSMUSG00000063157.
DR Ensembl; ENSMUST00000199624; ENSMUSP00000143409; ENSMUSG00000063157.
DR GeneID; 12991; -.
DR KEGG; mmu:12991; -.
DR UCSC; uc008xyu.2; mouse.
DR CTD; 1447; -.
DR MGI; MGI:88541; Csn2.
DR VEuPathDB; HostDB:ENSMUSG00000063157; -.
DR eggNOG; ENOG502RU0R; Eukaryota.
DR GeneTree; ENSGT00390000001890; -.
DR InParanoid; P10598; -.
DR OMA; LMHQIPQ; -.
DR OrthoDB; 1336883at2759; -.
DR PhylomeDB; P10598; -.
DR TreeFam; TF336929; -.
DR BioGRID-ORCS; 12991; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Csn2; mouse.
DR PRO; PR:P10598; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; P10598; protein.
DR Bgee; ENSMUSG00000063157; Expressed in thoracic mammary gland and 23 other tissues.
DR ExpressionAtlas; P10598; differential.
DR Genevisible; P10598; MM.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; ISO:MGI.
DR GO; GO:0007595; P:lactation; ISO:MGI.
DR GO; GO:2000117; P:negative regulation of cysteine-type endopeptidase activity; ISO:MGI.
DR InterPro; IPR001588; Casein.
DR InterPro; IPR016345; Casein_beta.
DR InterPro; IPR031305; Casein_CS.
DR PANTHER; PTHR11500; PTHR11500; 1.
DR Pfam; PF00363; Casein; 1.
DR PIRSF; PIRSF002372; Beta-casein; 1.
DR PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE 2: Evidence at transcript level;
KW Milk protein; Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000250"
FT CHAIN 16..231
FT /note="Beta-casein"
FT /id="PRO_0000004477"
FT MOD_RES 23
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9GKK3"
FT MOD_RES 26
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9GKK3"
FT MOD_RES 28
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05814"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05814"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05814"
FT CONFLICT 3
FT /note="V -> T (in Ref. 5; AAH19189)"
FT /evidence="ECO:0000305"
FT CONFLICT 41
FT /note="Missing (in Ref. 4; BAB32374/BAB32375 and 5;
FT AAH19114/AAH19189)"
FT /evidence="ECO:0000305"
FT CONFLICT 145
FT /note="S -> C (in Ref. 4; BAB32374)"
FT /evidence="ECO:0000305"
FT CONFLICT 156
FT /note="Q -> R (in Ref. 5; AAH13332)"
FT /evidence="ECO:0000305"
FT CONFLICT 165..166
FT /note="VV -> GG (in Ref. 4; BAB32375)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="L -> V (in Ref. 4; BAB32374)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="T -> P (in Ref. 4; BAB32374/BAB32375)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 231 AA; 25337 MW; 7DD7DFF0766A9422 CRC64;
MKVFILACLV ALALARETTF TVSSETDSIS SEESVEHINE QKLQKVNLMG QLQAEDVLQA
KVHSSIQSQP QAFPYAQAQT ISCNPVPQNI QPIAQPPVVP SLGPVISPEL ESFLKAKATI
LPKHKQMPLL NSETVLRLIN SQIPSLASLA NLHLPQSLVQ LLAQVVQAFP QTHLVSSQTQ
LSLPQSKVLY FLQQVAPFLP QDMSVQDLLQ YLELLNPTVQ FPATPQHSVS V
