ID   CASB_NOTEU              Reviewed;         302 AA.
AC   P28550;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Beta-casein;
DE   Flags: Precursor;
GN   Name=CSN2;
OS   Notamacropus eugenii (Tammar wallaby) (Macropus eugenii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Notamacropus.
OX   NCBI_TaxID=9315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=1543530; DOI=10.1677/jme.0.0080013;
RA   Collet C., Joseph R., Nicholas K.R.;
RT   "Molecular characterization and in-vitro hormonal requirements for
RT   expression of two casein genes from a marsupial.";
RL   J. Mol. Endocrinol. 8:13-20(1992).
CC   -!- FUNCTION: Important role in determination of the surface properties of
CC       the casein micelles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- INDUCTION: Maximal induction is dependent upon prolactin and insulin.
CC   -!- SIMILARITY: Belongs to the beta-casein family. {ECO:0000305}.
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DR   EMBL; X54715; CAA38518.1; -; mRNA.
DR   PIR; S21357; S21357.
DR   AlphaFoldDB; P28550; -.
DR   SMR; P28550; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR016345; Casein_beta.
DR   PANTHER; PTHR11500; PTHR11500; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Repeat; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..302
FT                   /note="Beta-casein"
FT                   /id="PRO_0000004476"
FT   REPEAT          144..151
FT                   /note="1"
FT   REPEAT          152..159
FT                   /note="2"
FT   REPEAT          160..167
FT                   /note="3"
FT   REPEAT          168..175
FT                   /note="4"
FT   REPEAT          176..182
FT                   /note="5"
FT   REPEAT          183..190
FT                   /note="6"
FT   REPEAT          191..198
FT                   /note="7"
FT   REPEAT          199..204
FT                   /note="8"
FT   REPEAT          205..214
FT                   /note="9"
FT   REPEAT          215..222
FT                   /note="10"
FT   REPEAT          223..230
FT                   /note="11"
FT   REPEAT          231..238
FT                   /note="12"
FT   REPEAT          241..247
FT                   /note="13"
FT   REPEAT          248..255
FT                   /note="14"
FT   REPEAT          256..262
FT                   /note="15"
FT   REPEAT          263..269
FT                   /note="16"
FT   REGION          144..269
FT                   /note="16 X approximate tandem repeats"
FT   MOD_RES         23
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
SQ   SEQUENCE   302 AA;  35882 MW;  2428DD348ECBA227 CRC64;
     MKLLILTCLV ALGFARPMVE KISESEEYVN EVPEKRLKRR FPVKNEHQVE INHHLRPESE
     MMSLYYQPFY WSEEMRNLKM TSLPKDRRMA VLKSTVSDEV FPSLQHKSLS LPKSKVQPLS
     RQQILTFHTL QMVPLSHKLL TTPKREMLPI YERERLPAHK RESLLAHERE SLLAHERDIL
     VPQREMSFVP EREFLFASER VVLPEQEKEI LHNDEREVLA VHKKEILPPF EKEKVLPLLQ
     HRVVPLPQRE IVPPFQRETL LPEEILPVNQ WELMPEVVPF DPYPFLQPVA PFYYSTELNE
     KN