CASB_PIG
ID CASB_PIG Reviewed; 232 AA.
AC P39037;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Beta-casein;
DE Flags: Precursor;
GN Name=CSN2;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mammary gland;
RX PubMed=1503277; DOI=10.1111/j.1365-2052.1992.tb00160.x;
RA Alexander L.J., Beattie C.W.;
RT "The sequence of porcine beta-casein cDNA.";
RL Anim. Genet. 23:369-371(1992).
RN [2]
RP PROTEIN SEQUENCE OF 16-29.
RC TISSUE=Milk;
RX PubMed=12162653; DOI=10.2527/2002.8071863x;
RA Kauf A.C.W., Kensinger R.S.;
RT "Purification of porcine beta-casein, N-terminal sequence, quantification
RT in mastitic milk.";
RL J. Anim. Sci. 80:1863-1870(2002).
RN [3]
RP CHARACTERIZATION.
RC TISSUE=Milk;
RX PubMed=385058; DOI=10.1016/0005-2795(79)90162-4;
RA Mulvihill D.M., Fox P.F.;
RT "Isolation and characterization of porcine beta-casein.";
RL Biochim. Biophys. Acta 578:317-324(1979).
CC -!- FUNCTION: Important role in determination of the surface properties of
CC the casein micelles.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC -!- SIMILARITY: Belongs to the beta-casein family. {ECO:0000305}.
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DR EMBL; X54974; CAA38718.1; -; mRNA.
DR PIR; A48384; A48384.
DR RefSeq; NP_999599.1; NM_214434.2.
DR AlphaFoldDB; P39037; -.
DR SMR; P39037; -.
DR STRING; 9823.ENSSSCP00000009875; -.
DR iPTMnet; P39037; -.
DR PaxDb; P39037; -.
DR PeptideAtlas; P39037; -.
DR PRIDE; P39037; -.
DR Ensembl; ENSSSCT00015089608; ENSSSCP00015036577; ENSSSCG00015066703.
DR Ensembl; ENSSSCT00030072195; ENSSSCP00030032915; ENSSSCG00030051810.
DR GeneID; 404088; -.
DR KEGG; ssc:404088; -.
DR CTD; 1447; -.
DR eggNOG; ENOG502RU0R; Eukaryota.
DR HOGENOM; CLU_106775_0_0_1; -.
DR InParanoid; P39037; -.
DR OrthoDB; 1336883at2759; -.
DR TreeFam; TF336929; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR Genevisible; P39037; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR InterPro; IPR001588; Casein.
DR InterPro; IPR016345; Casein_beta.
DR PANTHER; PTHR11500; PTHR11500; 1.
DR Pfam; PF00363; Casein; 1.
DR PIRSF; PIRSF002372; Beta-casein; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Milk protein; Phosphoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000269|PubMed:12162653"
FT CHAIN 16..232
FT /note="Beta-casein"
FT /id="PRO_0000004478"
FT REGION 48..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9GKK3"
FT MOD_RES 27
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9GKK3"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05814"
FT MOD_RES 32
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05814"
FT MOD_RES 33
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05814"
FT MOD_RES 34
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05814"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 232 AA; 25949 MW; 6284850F40F7365C CRC64;
MKLLILACFV ALALARAKEE LNASGETVES LSSSEESITH ISKEKIEKLK REEQQQTENE
RQNKIHQFPQ PQPLAHPYTE PIPYPILPQN ILPLAQVPVV VPLLHPEVMK DSKAKETIVP
KRKGMPFPKS PAEPFVEGQS LTLTDFEVLS LPLLQSLMHQ IPQPVPQTPM FAPQPLLSLP
QAKVLPVPQQ VVPFPQRDMP FQALLLYQDP LLGPLQGFYP VPQPVAPVYN PV
