ID   CASB_RABIT              Reviewed;         228 AA.
AC   P09116;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Beta-casein;
DE   Flags: Precursor;
GN   Name=CSN2;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Mammary gland;
RX   PubMed=3211753; DOI=10.1093/nar/16.24.11814;
RA   Schaerer E., Devinoy E., Kraehenbuhl J.-P., Houdebine L.-M.;
RT   "Sequence of the rabbit beta-casein cDNA: comparison with other casein cDNA
RT   sequences.";
RL   Nucleic Acids Res. 16:11814-11814(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=1999295; DOI=10.1016/0378-1119(91)90067-l;
RA   Thepot D., Devinoy E., Fontaine M.-L., Houdebine L.-M.;
RT   "Structure of the gene encoding rabbit beta-casein.";
RL   Gene 97:301-306(1991).
CC   -!- FUNCTION: Important role in determination of the surface properties of
CC       the casein micelles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the beta-casein family. {ECO:0000305}.
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DR   EMBL; X13043; CAA31449.1; -; mRNA.
DR   EMBL; M33582; AAA31168.1; -; Genomic_DNA.
DR   PIR; JT0564; JT0564.
DR   RefSeq; NP_001076228.2; NM_001082759.2.
DR   AlphaFoldDB; P09116; -.
DR   STRING; 9986.ENSOCUP00000008186; -.
DR   Allergome; 2149; Ory c 8.
DR   PRIDE; P09116; -.
DR   GeneID; 100009539; -.
DR   KEGG; ocu:100009539; -.
DR   CTD; 1447; -.
DR   eggNOG; ENOG502RU0R; Eukaryota.
DR   InParanoid; P09116; -.
DR   OrthoDB; 1336883at2759; -.
DR   TreeFam; TF336929; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001588; Casein.
DR   InterPro; IPR016345; Casein_beta.
DR   InterPro; IPR031305; Casein_CS.
DR   PANTHER; PTHR11500; PTHR11500; 1.
DR   Pfam; PF00363; Casein; 1.
DR   PIRSF; PIRSF002372; Beta-casein; 1.
DR   PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..228
FT                   /note="Beta-casein"
FT                   /id="PRO_0000004479"
FT   MOD_RES         30
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   MOD_RES         32
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   MOD_RES         33
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   MOD_RES         34
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   CONFLICT        87
FT                   /note="I -> T (in Ref. 2; AAA31168)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   228 AA;  26072 MW;  16BB2D7C78887E8A CRC64;
     MKVLILACLV ALALAREKEQ LSVPTEAVGS VSSSEEITHI NKQKLETIKH VEQLLREEKL
     QDKILPFIQS LFPFAERIPY PTLPQNILNL AQLDMLLPLL QPEIMEDPKA KETIIPKHKL
     MPFLKSPKTV PFVDSQILNL REMKNQHLLL PQLLPFMHQV FQPFPQTPIP YPQALLSLPQ
     SKFMPIVPQV VPYPQRDMPI QALQLFQELL FPTHQGYPVV QPIAPVNV