ID   CASB_RAT                Reviewed;         231 AA.
AC   P02665;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Beta-casein;
DE   Flags: Precursor;
GN   Name=Csn2; Synonyms=Csnb;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6283475; DOI=10.1093/nar/10.7.2295;
RA   Blackburn D.E., Hobbs A.A., Rosen J.M.;
RT   "Rat beta casein cDNA: sequence analysis and evolutionary comparisons.";
RL   Nucleic Acids Res. 10:2295-2307(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=3997858; DOI=10.1016/s0021-9258(18)88885-8;
RA   Jones W.K., Yu-Lee L., Clift S.M., Brown T.L., Rosen J.M.;
RT   "The rat casein multigene family. Fine structure and evolution of the beta-
RT   casein gene.";
RL   J. Biol. Chem. 260:7042-7050(1985).
CC   -!- FUNCTION: Important role in determination of the surface properties of
CC       the casein micelles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the beta-casein family. {ECO:0000305}.
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DR   EMBL; J00711; AAA40878.1; -; mRNA.
DR   EMBL; M11178; AAA40879.1; -; Genomic_DNA.
DR   EMBL; M11175; AAA40879.1; JOINED; Genomic_DNA.
DR   EMBL; M11176; AAA40879.1; JOINED; Genomic_DNA.
DR   EMBL; M11177; AAA40879.1; JOINED; Genomic_DNA.
DR   PIR; A93420; KBRT.
DR   RefSeq; NP_058816.2; NM_017120.3.
DR   AlphaFoldDB; P02665; -.
DR   SMR; P02665; -.
DR   STRING; 10116.ENSRNOP00000057016; -.
DR   BindingDB; P02665; -.
DR   ChEMBL; CHEMBL2210; -.
DR   DrugCentral; P02665; -.
DR   Allergome; 2151; Rat n 8.
DR   PaxDb; P02665; -.
DR   GeneID; 29173; -.
DR   KEGG; rno:29173; -.
DR   UCSC; RGD:61981; rat.
DR   CTD; 1447; -.
DR   RGD; 61981; Csn2.
DR   eggNOG; ENOG502RU0R; Eukaryota.
DR   InParanoid; P02665; -.
DR   OrthoDB; 1336883at2759; -.
DR   PhylomeDB; P02665; -.
DR   PRO; PR:P02665; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; ISO:RGD.
DR   GO; GO:0007595; P:lactation; ISO:RGD.
DR   GO; GO:2000117; P:negative regulation of cysteine-type endopeptidase activity; ISO:RGD.
DR   InterPro; IPR001588; Casein.
DR   InterPro; IPR016345; Casein_beta.
DR   InterPro; IPR031305; Casein_CS.
DR   PANTHER; PTHR11500; PTHR11500; 1.
DR   Pfam; PF00363; Casein; 1.
DR   PIRSF; PIRSF002372; Beta-casein; 1.
DR   PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..231
FT                   /note="Beta-casein"
FT                   /id="PRO_0000004480"
FT   MOD_RES         24
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GKK3"
FT   MOD_RES         27
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GKK3"
FT   MOD_RES         29
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   MOD_RES         31
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   MOD_RES         32
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P05814"
FT   CONFLICT        71
FT                   /note="Q -> K (in Ref. 1; AAA40878)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        100
FT                   /note="V -> D (in Ref. 1; AAA40878)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        113
FT                   /note="K -> E (in Ref. 2; AAA40879)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        115
FT                   /note="K -> E (in Ref. 2; AAA40879)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   231 AA;  25369 MW;  39DC950A97FC0FCA CRC64;
     MKVFILACLV ALALAREKDA FTVSSETGSI SSEESVEHIN EKLQKVKLMG QVQSEDVLQN
     KFHSGIQSEP QAIPYAQTIS CSPIPQNIQP IAQPPVVPTV GPIISPELES FLKAKATVLP
     KHKQMPFLNS ETVLRLFNSQ IPSLDLANLH LPQSPAQLQA QIVQAFPQTP AVVSSQPQLS
     HPQSKSQYLV QQLAPLFQQG MPVQDLLQYL DLLLNPTLQF LATQQLHSTS V