ID   Y5695_STRCO             Reviewed;         430 AA.
AC   Q9KYS0;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Putative zinc metalloprotease SCO5695;
DE            EC=3.4.24.-;
GN   OrderedLocusNames=SCO5695; ORFNames=SC5H4.19;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family. {ECO:0000305}.
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DR   EMBL; AL939124; CAB91131.1; -; Genomic_DNA.
DR   RefSeq; NP_629823.1; NC_003888.3.
DR   RefSeq; WP_011030397.1; NZ_VNID01000024.1.
DR   AlphaFoldDB; Q9KYS0; -.
DR   STRING; 100226.SCO5695; -.
DR   GeneID; 1101134; -.
DR   KEGG; sco:SCO5695; -.
DR   PATRIC; fig|100226.15.peg.5784; -.
DR   eggNOG; COG0750; Bacteria.
DR   HOGENOM; CLU_025778_1_2_11; -.
DR   InParanoid; Q9KYS0; -.
DR   OMA; QYMVGFG; -.
DR   PhylomeDB; Q9KYS0; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   PANTHER; PTHR42837; PTHR42837; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Metal-binding; Metalloprotease;
KW   Protease; Reference proteome; Transmembrane; Transmembrane helix; Zinc.
FT   CHAIN           1..430
FT                   /note="Putative zinc metalloprotease SCO5695"
FT                   /id="PRO_0000088465"
FT   TRANSMEM        122..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          146..227
FT                   /note="PDZ"
FT   ACT_SITE        21
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         20
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         24
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
SQ   SEQUENCE   430 AA;  46240 MW;  3586AEBD3FD1F44F CRC64;
     MFILGIVLFA VGLLFSIAWH ELGHLSTAKM FGIRVPQYMV GFGPTLFSKK KGDTEYGVKA
     IPFGGYIRMI GMFPPGPDGR MEARSTSPWR GMIEDARSAA FEELQPGDEK RLFYTRKPWK
     RVIVMFAGPF MNLILAVVLF LTVLMGFGIS QQTTTVSSVS QCVISQSENP DDCAKSDPAS
     PAAAAGLRAG DKILAFDGVR TDDWDKLSDL IRANPGEDVP VVVERKGEEI TLHATIATNK
     VAKKDSNGQI VQGEYVTAGF LGFSSATGVV KQDFGQSVTW MGDRIGDAVD NLAALPAKIP
     ALWDAAFGDG PREADSPMGV VGAARVGGEI ATLDIPPTQQ LAMFVMLVAG FNLSLFLFNM
     LPLLPLDGGH IAGALWESLR RATAKVLRRP DPGPFDVAKL MPVAYVVAGV FVCFTLLVLV
     ADVVNPVRIT