ID   Y56_MYCSE               Reviewed;         105 AA.
AC   L8FL29; A0A2U9PH48;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2013, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Uncharacterized EspC-like protein D806_0056;
GN   ORFNames=0056 {ECO:0000303|PubMed:23618714},
GN   D806_000530 {ECO:0000312|EMBL:AWT51047.1}, D806_0056;
OS   Mycolicibacterium smegmatis (strain MKD8) (Mycobacterium smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=1214915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MKD8;
RX   PubMed=23618714; DOI=10.1128/genomea.00148-13;
RA   Gray T.A., Palumbo M.J., Derbyshire K.M.;
RT   "Draft genome sequence of MKD8, a conjugal recipient Mycobacterium
RT   smegmatis strain.";
RL   Genome Announc. 1:E0014813-E0014813(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MKD8;
RA   Derbyshire K., Gray T.A., Champion M.;
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700084 / mc(2)155, and MKD8;
RX   PubMed=18554329; DOI=10.1111/j.1365-2958.2008.06299.x;
RA   Coros A., Callahan B., Battaglioli E., Derbyshire K.M.;
RT   "The specialized secretory apparatus ESX-1 is essential for DNA transfer in
RT   Mycobacterium smegmatis.";
RL   Mol. Microbiol. 69:794-808(2008).
CC   -!- FUNCTION: May be involved in assembly of the ESX-1 / type VII
CC       specialized secretion system (T7SS), which exports several proteins
CC       including EsxA and EsxB (Probable). Involved in DNA conjugation, in at
CC       least recipient strain (PubMed:18554329).
CC       {ECO:0000269|PubMed:18554329}.
CC   -!- DISRUPTION PHENOTYPE: Loss of DNA conjugation when disrupted in
CC       recipient strain, strain does not secrete EsxB (PubMed:18554329).
CC       {ECO:0000269|PubMed:18554329}.
CC   -!- MISCELLANEOUS: DNA conjugation in M.smegmatis is unidirectional with
CC       distinct donor and recipient strains; mc(2)155 is a donor strain while
CC       MKD8 is a recipient strain. Mutations in a donor strain that alter DNA
CC       transfer do not always alter DNA transfer in a recipient strain.
CC       {ECO:0000305|PubMed:18554329}.
CC   -!- SIMILARITY: Belongs to the EspC family. {ECO:0000305}.
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DR   EMBL; CP027541; AWT51047.1; -; Genomic_DNA.
DR   RefSeq; WP_003891383.1; NZ_CP027541.1.
DR   AlphaFoldDB; L8FL29; -.
DR   SMR; L8FL29; -.
DR   EnsemblBacteria; AWT51047; AWT51047; D806_000530.
DR   GeneID; 66738246; -.
DR   PATRIC; fig|1214915.3.peg.56; -.
DR   HOGENOM; CLU_173991_0_0_11; -.
DR   Proteomes; UP000011200; Chromosome.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   InterPro; IPR022536; EspC.
DR   Pfam; PF10824; T7SS_ESX_EspC; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..105
FT                   /note="Uncharacterized EspC-like protein D806_0056"
FT                   /id="PRO_0000438356"
SQ   SEQUENCE   105 AA;  11130 MW;  80E48762E658B850 CRC64;
     MSDDLRVTTA HLRELSAKQG RAAAELATAT AVVDGVDTAL RFTHGPISWG TAAAVEAVQH
     ARRAAGTGMV KVSQELETKL DTAAGRYHRT DSTMGDALDE TIQPR