ID   Y574_MYCA1              Reviewed;         309 AA.
AC   A0QAB6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Uncharacterized tRNA/rRNA methyltransferase MAV_0574;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MAV_0574;
OS   Mycobacterium avium (strain 104).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=243243;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=104;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family. {ECO:0000305}.
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DR   EMBL; CP000479; ABK67417.1; -; Genomic_DNA.
DR   RefSeq; WP_009974760.1; NC_008595.1.
DR   AlphaFoldDB; A0QAB6; -.
DR   SMR; A0QAB6; -.
DR   EnsemblBacteria; ABK67417; ABK67417; MAV_0574.
DR   GeneID; 66692281; -.
DR   KEGG; mav:MAV_0574; -.
DR   HOGENOM; CLU_021322_0_0_11; -.
DR   OMA; QVPPYEY; -.
DR   OrthoDB; 1422015at2; -.
DR   Proteomes; UP000001574; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   PANTHER; PTHR46429; PTHR46429; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF75217; SSF75217; 1.
DR   TIGRFAMs; TIGR00186; rRNA_methyl_3; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..309
FT                   /note="Uncharacterized tRNA/rRNA methyltransferase
FT                   MAV_0574"
FT                   /id="PRO_0000379569"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         261
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         281
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         290
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   309 AA;  32285 MW;  4011B0920EE460C5 CRC64;
     MAGNSRRRGA VRKAGTKKGP TVGSGGQRRR GLEGRGPTPP AHLRPNHPAA KRAQSPPRRP
     AKRTEETETV LGRNPVLECL RAGVPATALY VALGTEADER LTESVSRAAD SGISILEVPR
     ADLDRMTGNH LHQGIALQVP PYIYAHPDDL LEAAAGSPPA LLVALDNISD PRNLGAIVRS
     VAAFGGHGVL IPQRRSASVT AVAWRTSAGA AARIPVARAT NLTRTLQDWA DRGLRVIGLD
     AGGDTTLDDL DGSDPLVVVV GSEGKGLSRL VRQNCDEVVS IPMAGSAESL NASVAAGVVL
     AEISRQRRG