Y5758_ARATH
ID Y5758_ARATH Reviewed; 548 AA.
AC Q9LF66;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=BTB/POZ domain-containing protein At5g17580;
GN OrderedLocusNames=At5g17580; ORFNames=K10A8_60;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP DOMAIN BTB.
RX PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA Vierstra R.D.;
RT "Cullins 3a and 3b assemble with members of the broad
RT complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL J. Biol. Chem. 280:18810-18821(2005).
CC -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00982}.
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DR EMBL; AL391151; CAC01902.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92445.1; -; Genomic_DNA.
DR PIR; T51462; T51462.
DR RefSeq; NP_197260.1; NM_121764.2.
DR AlphaFoldDB; Q9LF66; -.
DR SMR; Q9LF66; -.
DR PaxDb; Q9LF66; -.
DR PRIDE; Q9LF66; -.
DR ProteomicsDB; 242840; -.
DR EnsemblPlants; AT5G17580.1; AT5G17580.1; AT5G17580.
DR GeneID; 831624; -.
DR Gramene; AT5G17580.1; AT5G17580.1; AT5G17580.
DR KEGG; ath:AT5G17580; -.
DR Araport; AT5G17580; -.
DR TAIR; locus:2151411; AT5G17580.
DR eggNOG; ENOG502QQV1; Eukaryota.
DR HOGENOM; CLU_005994_6_2_1; -.
DR InParanoid; Q9LF66; -.
DR OMA; KHRHLTE; -.
DR PhylomeDB; Q9LF66; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9LF66; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LF66; baseline and differential.
DR Genevisible; Q9LF66; AT.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR043454; NPH3/RPT2-like.
DR InterPro; IPR027356; NPH3_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR32370; PTHR32370; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF03000; NPH3; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS51649; NPH3; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Phosphoprotein; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..548
FT /note="BTB/POZ domain-containing protein At5g17580"
FT /id="PRO_0000409584"
FT DOMAIN 7..74
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 180..442
FT /note="NPH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
FT COILED 442..493
FT /evidence="ECO:0000255"
FT MOD_RES 383
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q9FMF5"
SQ SEQUENCE 548 AA; 62932 MW; E14F345D6938A03C CRC64;
MSASYVSDLH INVKGVPFHL CKEMLAKRSS KVSSLLERNE IDELRLILRD LEVDPETFEL
VARFCNGSEF KFTSDTIVSV LCIAYYLGMN EEQSSNNLLG KASEFLEHRV FPSWSETINA
LRSGDKSFDK LADVGLVDVF FDSLIEKASY DPRLLGELIK NRAETDDYRP NPRRRLFVID
WKSEDLITIP LRLYEPFMIR AIKSRSIPVE YIVLSVCKYA KKWVFDTEES LSGQKREAIE
VVERLLPYQR GLISCELLFE SLKHSIWLEA SSECQNGFMI RICKQLDMAK STDLKILSRG
YGEKAEGFEN IELVKTVVKS FYTYYANEDS ETVSHFVKVA KLSEEFLFLA ASEASLKLEA
FVELAEMTVA VSQGILSYSD GIYRAIDVFL ESHRYLTESE KMEVCKVLEC GKLSQEGFER
AAKNQKLPLR IVVNVLCVSQ LQIRDTVAKE IKGMEEKVDE EEEEEIEVSS DEDEMEKMSN
KLLGLEIEND ECVVHRRKNM KKKKKKISVW GQVKRKFGCL NSSSSSYSVD ACTCDVKKKK
KKIHHHYE
