ID   Y577_TREPA              Reviewed;         614 AA.
AC   O83586;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Uncharacterized protein TP_0577;
GN   OrderedLocusNames=TP_0577;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AE000520; AAC65558.1; -; Genomic_DNA.
DR   PIR; G71306; G71306.
DR   RefSeq; WP_010882023.1; NC_021490.2.
DR   AlphaFoldDB; O83586; -.
DR   STRING; 243276.TPANIC_0577; -.
DR   EnsemblBacteria; AAC65558; AAC65558; TP_0577.
DR   KEGG; tpa:TP_0577; -.
DR   eggNOG; ENOG5032HA5; Bacteria.
DR   HOGENOM; CLU_444757_0_0_12; -.
DR   OMA; TMSENAD; -.
DR   OrthoDB; 776672at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..614
FT                   /note="Uncharacterized protein TP_0577"
FT                   /id="PRO_0000202277"
FT   TRANSMEM        494..516
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        552..574
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          588..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   614 AA;  68121 MW;  1A748160AA5F8F8D CRC64;
     MRNGEYSRSH GRSVRTVHPF LLGVSVYQYP VCRTTVNGSY AQSFAALLFF PQIAVAFSAT
     APAPSFDSFL SARQRHPPAS SFLASPAAPT HPLFATARTT AAQLLSTPPA PARPRPRPDH
     VIPKEKWRLA VADFTFHGIP KIFQRYVRPA RELLFIELKK LPLRHFLSEA EQRERAALPH
     EEAYHARLKE RAHLQRARDF VSLHPVSDHA RRLRTAAFEK QIKEKEQEIE RARVEVRTAR
     ARFFRPWLQA EVLVLGAQNE PHALPERFHL ATHLRQKKLS ALVTGKLVDV AGYVRISLYL
     STGLEAEPTR EFTLAGPYRE LPRLMHTLSA QLRSAIENAQ PVRIVFDVHP PHARLSFQGV
     PVEDLSKPLI SYPGRYVVDV SAAGYFSATK EIYIENRPAF SLRVRLVARP QHRVRVQLTD
     NSAAPIFSGA RSVGVTPFST VVTDLREIFT VGPAGARSFA FIERGTFPNS QPSTLVLPAP
     NPNATQDLAY KRDVAYWSFG ALCIAVPIAL ILGSTLADTH QALERAKAAS AQPPPPPAPA
     GTGALERKSQ HLLIGTGVAV GVAVILSINF IVHAARYLNA VMHNAPQAVR PRADKDIQTL
     THRDEAEEDQ EEDS