Y5780_ARATH
ID Y5780_ARATH Reviewed; 559 AA.
AC Q9FIK1;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=BTB/POZ domain-containing protein At5g47800;
GN OrderedLocusNames=At5g47800; ORFNames=MCA23.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT features of the regions of 1,081,958 bp covered by seventeen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:379-391(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP DOMAIN BTB.
RX PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA Vierstra R.D.;
RT "Cullins 3a and 3b assemble with members of the broad
RT complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL J. Biol. Chem. 280:18810-18821(2005).
CC -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00982}.
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DR EMBL; AB016886; BAB11327.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95573.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68401.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68402.1; -; Genomic_DNA.
DR EMBL; BT005761; AAO64165.1; -; mRNA.
DR EMBL; BT006083; AAP04068.1; -; mRNA.
DR EMBL; AK228510; BAF00434.1; -; mRNA.
DR RefSeq; NP_001318755.1; NM_001344746.1.
DR RefSeq; NP_001330161.1; NM_001344748.1.
DR RefSeq; NP_199591.1; NM_124154.5.
DR AlphaFoldDB; Q9FIK1; -.
DR BioGRID; 20079; 1.
DR iPTMnet; Q9FIK1; -.
DR PaxDb; Q9FIK1; -.
DR PRIDE; Q9FIK1; -.
DR EnsemblPlants; AT5G47800.1; AT5G47800.1; AT5G47800.
DR EnsemblPlants; AT5G47800.3; AT5G47800.3; AT5G47800.
DR EnsemblPlants; AT5G47800.4; AT5G47800.4; AT5G47800.
DR GeneID; 834831; -.
DR Gramene; AT5G47800.1; AT5G47800.1; AT5G47800.
DR Gramene; AT5G47800.3; AT5G47800.3; AT5G47800.
DR Gramene; AT5G47800.4; AT5G47800.4; AT5G47800.
DR KEGG; ath:AT5G47800; -.
DR Araport; AT5G47800; -.
DR TAIR; locus:2160877; AT5G47800.
DR eggNOG; ENOG502QQZH; Eukaryota.
DR HOGENOM; CLU_005994_5_2_1; -.
DR InParanoid; Q9FIK1; -.
DR OMA; ISYLLHK; -.
DR PhylomeDB; Q9FIK1; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9FIK1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FIK1; baseline and differential.
DR Genevisible; Q9FIK1; AT.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR043454; NPH3/RPT2-like.
DR InterPro; IPR027356; NPH3_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR32370; PTHR32370; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF03000; NPH3; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS51649; NPH3; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..559
FT /note="BTB/POZ domain-containing protein At5g47800"
FT /id="PRO_0000409585"
FT DOMAIN 28..96
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 199..476
FT /note="NPH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
FT REGION 477..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 417
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q9FMF5"
SQ SEQUENCE 559 AA; 63302 MW; 314A50104266C8AE CRC64;
MKFMKIGTKP DTFYTQEASR ILITDTPNDL VIRINNTTYH LHRSCLVPKC GLLRRLCTDL
EESDTVTIEL NDIPGGADAF ELCAKFCYDI TINLSAHNLV NALCASKFLR MSDSVDKGNL
LPKLEAFFHS CILQGWKDSI VTLQSTTKLP EWCENLGIVR KCIDSIVEKI LTPTSEVSWS
HTYTRPGYAK RQHHSVPRDW WTEDISDLDL DLFRCVITAA RSTFTLPPQL IGEALHVYTC
RWLPYFKSNS HSGFSVKENE AALERHRRLV NTVVNMIPAD KGSVSEGFLL RLVSIASYVR
ASLTTKTELI RKSSLQLEEA TLEDLLLPSH SSSHLHRYDT DLVATVLESF LMLWRRQSSA
HLSSNNTQLL HSIRKVAKLI DSYLQAVAQD VHMPVSKFVS LSEAVPDIAR QSHDRLYKAI
NIFLKVHPEI SKEEKKRLCR SLDCQKLSAQ VRAHAVKNER MPLRTVVQAL FFDQESGSKG
ASSRSESQEL FTRGKETPTD EHSMMHKLHL GPASTGKAKN VLEEGCKRGE EKTRSSTDPK
KIVWKGTGSE HKHHISRDR
