Y5795_DICDI
ID Y5795_DICDI Reviewed; 808 AA.
AC Q1ZXL0; Q86H71;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=PH domain-containing protein DDB_G0275795;
GN ORFNames=DDB_G0275795;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
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DR EMBL; AAFI02000013; EAS66916.1; -; Genomic_DNA.
DR RefSeq; XP_001134600.1; XM_001134600.1.
DR AlphaFoldDB; Q1ZXL0; -.
DR SMR; Q1ZXL0; -.
DR PaxDb; Q1ZXL0; -.
DR EnsemblProtists; EAS66916; EAS66916; DDB_G0275795.
DR GeneID; 8620030; -.
DR KEGG; ddi:DDB_G0275795; -.
DR dictyBase; DDB_G0275795; -.
DR eggNOG; ENOG502RSR6; Eukaryota.
DR HOGENOM; CLU_348984_0_0_1; -.
DR InParanoid; Q1ZXL0; -.
DR OMA; WAHEIAS; -.
DR PRO; PR:Q1ZXL0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0032009; C:early phagosome; IDA:dictyBase.
DR GO; GO:0044354; C:macropinosome; IDA:dictyBase.
DR GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IDA:dictyBase.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:1905161; P:protein localization to phagocytic vesicle; IMP:dictyBase.
DR GO; GO:0001881; P:receptor recycling; IBA:GO_Central.
DR GO; GO:1905162; P:regulation of phagosome maturation; IMP:dictyBase.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR045188; Boi1/Boi2-like.
DR InterPro; IPR033931; PDK1-typ_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22902; PTHR22902; 1.
DR Pfam; PF14593; PH_3; 1.
DR SMART; SM00233; PH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil; Reference proteome.
FT CHAIN 1..808
FT /note="PH domain-containing protein DDB_G0275795"
FT /id="PRO_0000368213"
FT DOMAIN 124..216
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 108..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 57..121
FT /evidence="ECO:0000255"
FT COILED 322..412
FT /evidence="ECO:0000255"
FT COILED 487..645
FT /evidence="ECO:0000255"
FT COILED 678..734
FT /evidence="ECO:0000255"
FT COMPBIAS 108..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 808 AA; 94135 MW; F895318FBA76F928 CRC64;
MSSVRAQFAE VQEQLNQVHS LVDSNTPSDL NKAATILKSL LPVYKDLSGN EESKRPENLE
ILKEIKSRLT EETQRVMSKK EEAKSLQIQQ QQQQQQLLQQ QQQQQILEST TRNRQASQQE
LPKPPILSGY LKKQGDKGLV RSFKKRWFLQ RDTKLFYYEK EGDSEPYGFV NLPEMINVKT
VDSGFELATP SRVYVFQVFK PSDLTYWTEG LKEFKKYYQS LQNSQKFGAN ANGNGNSSPN
MSSSGSYSDF RKYSESSQQP LNSSTGAINT TPQRGTPIKD RRGTVSGGTT EYSHSSSSTA
PDSPTLSSSY VPPPSSSNLN PQDEELKRRE NEIIRKHQEK LKQQDDQQQD DKQQQQQQSQ
EPPQQQQQQQ EQLQSQPSQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQPPQTSPQN
SRHGSTNYSQ LQQQQQQPQQ QPQQQSSPQV IISNNNSPRF ESQQQQNNFH NNGSNINLES
FRQSIEDELN KKFLKEKQDL MEFEIKKRLE IESEIKKLQL QLDQTKTDAE EKQNKSSNEL
KKKKAEIEDY EARVTIITKR NEEMDAKIKE LESSRPVETF PHEFLWTEEV NSRDLLIASQ
SKRILELEEQ LKLKDNAVTV IKRENEMLRQ ETEKKDKYIN ELLEKGGGSG IHTNSNNNNN
SNNNNNNSNN NSNTDKIKES MVAHQTQNAF LLQEIQRLET QSQFKLDIKI QQIEELENQL
EQQLYQFHRF REAIIGTMSN EYCVKIEKEN LDVKKEYFQS LGVSIKLHRV KEGYFANIDI
NSLFDKVIKE NVHYRNWPEW ISNQFNQA
