Y5813_ARATH
ID Y5813_ARATH Reviewed; 625 AA.
AC Q9LUB9;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=BTB/POZ domain-containing protein At5g48130;
GN OrderedLocusNames=At5g48130; ORFNames=MIF21.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP DOMAIN BTB.
RX PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA Vierstra R.D.;
RT "Cullins 3a and 3b assemble with members of the broad
RT complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL J. Biol. Chem. 280:18810-18821(2005).
CC -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00982}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BX832348; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR EMBL; AB023039; BAA96993.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95622.1; -; Genomic_DNA.
DR EMBL; BX832348; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_199624.1; NM_124187.2.
DR AlphaFoldDB; Q9LUB9; -.
DR PaxDb; Q9LUB9; -.
DR PRIDE; Q9LUB9; -.
DR EnsemblPlants; AT5G48130.1; AT5G48130.1; AT5G48130.
DR GeneID; 834865; -.
DR Gramene; AT5G48130.1; AT5G48130.1; AT5G48130.
DR KEGG; ath:AT5G48130; -.
DR Araport; AT5G48130; -.
DR TAIR; locus:2164763; AT5G48130.
DR eggNOG; ENOG502QQT1; Eukaryota.
DR HOGENOM; CLU_005994_5_1_1; -.
DR InParanoid; Q9LUB9; -.
DR OMA; NFASQRK; -.
DR OrthoDB; 334749at2759; -.
DR PhylomeDB; Q9LUB9; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9LUB9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LUB9; baseline and differential.
DR Genevisible; Q9LUB9; AT.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR043454; NPH3/RPT2-like.
DR InterPro; IPR027356; NPH3_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR32370; PTHR32370; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF03000; NPH3; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS51649; NPH3; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..625
FT /note="BTB/POZ domain-containing protein At5g48130"
FT /id="PRO_0000409586"
FT DOMAIN 41..105
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 217..469
FT /note="NPH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
FT REGION 494..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 625 AA; 71363 MW; 211816A6787C3053 CRC64;
METFSLKDCS SVASSPISSP NISTLLKIKV LSWSKETGLP ASVHVRVCNK SFNLHKSLLC
AKSGYFKERE DQLSEIEIPQ EFPGGAETFE KIMLFIYGCP TLIHPFNIAG LRCAAQFLEM
TEQHSTGNLC ERFDLYLNQV VLQNWDDTLV VLKKCQDLVP WSEDLLIVSR CIESLAFTAC
MEILDPERRR EKPVIMLEGM VNQPWEYTNI ERIINQDTWI KDLTDLPFEF FKKIIGSLRR
QGMKERYVSP LVALYASKSV IPEGQTNTDI LQRALDLLLT RDKAYRFVPV GFYFACLAHN
LKHDTVLKLQ DQIVSLLHTA QPENFIYPKA GNRQVAFSQE LLTMESLFSV YVSTESERHL
TSSSSNVRVG KLWDIFLSRL PYDQEMKTTR FIELIETVPM SFRESHDQLY LAVNAFLQVH
TNISQEEKGS ICSYLNCQKL SQEASLELVK NEKMPLRLVV QALFIQQLNT HQAFKDCSDS
FRFTNSADFS GSVVPSSRPL TSQQSPCTDD ETGPRNRPLC FLMQKDATLD EFESTSFRIH
NLEEQLVSLK KSLHSHDNLK KPNCLGKRSA SRNKNTFGQV TTACIGSVSF TSQRKYANRL
LQILRRVNLF GSRKTNRSKA GESER
