ID   Y5813_SACEN             Reviewed;         508 AA.
AC   P34698; A4FLS2; O33630;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2012, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Uncharacterized MFS-type transporter SACE_5813;
GN   OrderedLocusNames=SACE_5813;
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC   2338;
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 289-508.
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC   2338;
RX   PubMed=1732208; DOI=10.1128/jb.174.3.725-735.1992;
RA   Andersen J.F., Hutchinson C.R.;
RT   "Characterization of Saccharopolyspora erythraea cytochrome P-450 genes and
RT   enzymes, including 6-deoxyerythronolide B hydroxylase.";
RL   J. Bacteriol. 174:725-735(1992).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AM420293; CAM04997.1; -; Genomic_DNA.
DR   EMBL; M83110; AAA26484.1; -; Genomic_DNA.
DR   PIR; C42606; C42606.
DR   RefSeq; WP_009943184.1; NZ_PDBV01000001.1.
DR   AlphaFoldDB; P34698; -.
DR   SMR; P34698; -.
DR   STRING; 405948.SACE_5813; -.
DR   EnsemblBacteria; CAM04997; CAM04997; SACE_5813.
DR   KEGG; sen:SACE_5813; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_000960_28_2_11; -.
DR   OMA; DNMVLTV; -.
DR   OrthoDB; 1108236at2; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..508
FT                   /note="Uncharacterized MFS-type transporter SACE_5813"
FT                   /id="PRO_0000066186"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        479..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        504..508
FT                   /note="RAPSR -> ASAVALTAVSATARRNLRAGGT (in Ref. 2;
FT                   AAA26484)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   508 AA;  51504 MW;  5ECFE455C38A9B02 CRC64;
     MTGRQREREQ RPQPQTGDQG HPRRWLILVA LCAALLVIVI DNTVLNVAIP EIGRTFDAST
     GELQAVLDSY VVVCGGLLVA AGALSDRCGR RRVMVAGLVV FGLTSAGAAL APSVWWLIGM
     RAAMGVGAAL VMPATLAIMV RVFPPHERPK AFAAWTAVGS VALGLGPLLG GALVDLWSWA
     GIFLVNLPFV AVALAGVVRL VPESRDPAAG APDLPSTVLV TTGMVALVWA VIAVPERGAL
     ATPVLAATAL AVVSLAWFGV RQRRASAPMV DFGLYRDRRF AGASSAIALI AVATGSTLFV
     LSQYLQLVRG HSAVVAGMAA LPLAAGSVVG SALGARAPAR IGYRACIVTG FAVTAAGFGV
     LAALGPDSGQ PHIAFGLLLC GFGTGFAGPA ATSTALGAVP ADRAGMGSAL NDTHQQLGIA
     FGVAVLGGLL STAYRAFLPT GVPHDASTSL AATLSFADER TSAALADAAR LAFTQAQSAT
     MTAGLACALA GAAVAMLSLR SGRRAPSR