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Y5837_DICDI
ID   Y5837_DICDI             Reviewed;        2200 AA.
AC   Q54MP8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Bromodomain and WD repeat-containing DDB_G0285837;
GN   ORFNames=DDB_G0285837;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
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DR   EMBL; AAFI02000080; EAL64540.1; -; Genomic_DNA.
DR   RefSeq; XP_638029.1; XM_632937.1.
DR   AlphaFoldDB; Q54MP8; -.
DR   STRING; 44689.DDB0220685; -.
DR   PaxDb; Q54MP8; -.
DR   PRIDE; Q54MP8; -.
DR   EnsemblProtists; EAL64540; EAL64540; DDB_G0285837.
DR   GeneID; 8625294; -.
DR   KEGG; ddi:DDB_G0285837; -.
DR   dictyBase; DDB_G0285837; -.
DR   eggNOG; KOG0644; Eukaryota.
DR   HOGENOM; CLU_231215_0_0_1; -.
DR   InParanoid; Q54MP8; -.
DR   OMA; DITDMCT; -.
DR   Reactome; R-DDI-1266695; Interleukin-7 signaling.
DR   Reactome; R-DDI-3247509; Chromatin modifying enzymes.
DR   Reactome; R-DDI-9013418; RHOBTB2 GTPase cycle.
DR   PRO; PR:Q54MP8; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.20.920.10; -; 1.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF47370; SSF47370; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   4: Predicted;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..2200
FT                   /note="Bromodomain and WD repeat-containing DDB_G0285837"
FT                   /id="PRO_0000384445"
FT   REPEAT          352..391
FT                   /note="WD 1"
FT   REPEAT          394..433
FT                   /note="WD 2"
FT   REPEAT          442..483
FT                   /note="WD 3"
FT   REPEAT          548..586
FT                   /note="WD 4"
FT   REPEAT          591..630
FT                   /note="WD 5"
FT   REPEAT          653..691
FT                   /note="WD 6"
FT   REPEAT          694..736
FT                   /note="WD 7"
FT   REPEAT          741..780
FT                   /note="WD 8"
FT   DOMAIN          1736..1806
FT                   /note="Bromo"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT   REGION          137..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          194..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          259..288
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          918..1180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1262..1297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1461..1538
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1662..1703
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1850..2200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..244
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        918..938
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        976..997
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1018..1035
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1053..1069
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1070..1085
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1112..1129
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1136..1162
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1163..1180
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1262..1289
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1853..1877
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1912..1929
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1940..1973
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1999..2015
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2028..2043
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2128..2147
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2168..2189
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2200 AA;  250132 MW;  7F8FB19A11121DCE CRC64;
     MENTENKILD KRKEYEKEIY NKEIDQCDDN NINREINYLV YRWLNSQNGI DKNLVTSLFQ
     DFNKNDLLPK KVNWLGQQEN FTSNELNEKY KHIQSDHIKS IFSSYRDLAI QHGHFSKLPF
     QINTLLGDNA YSMIPKGFND KKDNDNNGDN NLLNKEKIPD NNNNNNSSSS SSSNSNTNKK
     KIKVSYLYNR PQVVTPTALQ PENTTNTTTT TTATTTTTTT TTTTNNTNVQ TTPTNTTNTT
     LTTPPPQIPI LPTTVPDIDI QQQQQQQQQQ QQQTISKSKN EDINNNNNIL SIQRNRYKSF
     TMMRFTENPF DFSIPIPVKL SGQEVISKSL KSTSQLPISF YSNFKNSLIV YGHKAPTYCL
     QFDKSGRLYF TGSDDHLVKV WSTYSGRLIA TLRGHLGDIT DMCTSFDNSL LATASNDNVI
     RIWNLNSNQY DSIASLTGHD PSVNNTITSI SFLSNPTTRL LVSSDSFGQC KLWNLDKSNH
     VISLSLNDNG SQSTINTGNI NDEQIDTEMI TDAEVPILTA TTITTAITTT ATTATATIAT
     TTTTTTPGKT NEITGTTMNK GGTLIVASVD SSLKIWSTLF NPPKLVNTLE GHPTTILALQ
     YSHGSDAIVS GSYDGTVIIW RHSGGPKWDH VIFNIKNTQR PNQANSHPKK VARSKATFKN
     VIWSHDDRFI ITTDYNMIRV WNSLDGSFHL EMAEHTSEVY VTSCHPFDSR LIMSSGYDSQ
     VILWSIETGE IIKKFVLQEP GFQCQILDGC FSPDGQKFIV TNSTGKWFMF ELGLGSDINN
     LKKLVPNEQY FLTDYHPLIR DANGNVLDEL TQTPPHLMPR AMLVNYQGLP YPDHYNFTDQ
     DAIYHLEPYK NTSNYKRDLK IQKEFERREV YTFNQGNPSN IPSHPIVIFV ASEPKPQPKK
     IPKKPRRPWD QIEEEIIDDE IIFPSDPSDE DFNPSDASEN SSEDEQQQQH QQQQQDDDDD
     DDDDEDYDSD GKKMSTRKKS KIKADKRKKR LLKQSKKFTR RNTSPSKFNE IMNTFDLPED
     DDNNSNNNNR KAVSNKRLSN KQKKRYNLIN DGEIEMDDDD QYLNDNILDS DDNDYEHRNR
     YDNDEFSGSE SYNGSDGGGG GGDDDSDNSS DNSSENDSSA NGSDSDYSGS KSNKNKRGDK
     SKRNKKGKKN VKNKKVQKRG RKKSSTSSSS STSHNQNHLT ASALKKLNDI RKKKEILPVC
     PKWLSITSTT SETFYSPQVG DFIFYFYQGH TKYLEKFPPN GIESNLDNKS IVNYILNNNN
     INNNNNNNNN NNNNNNNNNN NNNNGVDDQQ INSDDDDSQK IIKKSYQECI IKNLNYFISP
     DGTHKVVITL LPVFDQQVPP QNQNDESNFY TVIYHVSDIP DYLVLASKVR KSMLTDWTVP
     NKRFRMFYPA SGWYNGTIIE ISDSDPLFPN SPWENIKVLW DDTEEEDRVN YWEIDEKFDD
     DQNPQKIKEI KDENENEKVI ENNQQQQQQQ PQQQPQQQPI QNNQQLSINN TNVNNNNNNN
     NNNNNNNNNN NNNNNNNNNN NNSLNGGLVD YSGNNNNNNN NNFNYNSNNN LSMSGILDYT
     NFNNNNNNFM NYNMYQGNYN GMMMNNNTSN YSYLDPNNSN MYMQTYPQNS TMQNQQQPQL
     NNIYYNSQLQ PTNYNYTNNF NTNYSNFNNS SSNIMNYNTN NNFNSPPTAT TSNTTTTTTT
     TTETSNNNNN NNNNNNNNNN NNNFKDNILR IKIQYVESIE DEKIENLKKE MKEFLENDEI
     TDIYSEPVDL KLYPLYIRFV PHPMDISTII KRLESSYYRS LDAIYFDAKL IMIDAYVYNK
     PNTMVAKNSK LVFHRISDIL KEAANYTPSD ILLQSGGSFD SFTLKSMAAD KDDSQLDDED
     DSMVSGVTND DDDDDDNLAN NNHGNNKSRN GDGLEGDISI SDSEHDNSKT GKNITRSLLS
     PSEDEGGINV NRTPSKRGRK KANATTTTTT TTTTTSSTPS KRLITGRLTR SRSNQSNEES
     DDDGFIDDNN SSHQNGGKIL DDSDNDDKNQ NGTDNDYNDD DDDDDNDGDS TNKKRKSIKN
     QTEPITKRQR TNRLIFEDED EDDNNQEEDE EDYQEKPKPK PRSKQTTPKV TTPRKRGRKK
     IDQSEEEEDE DQSDVNSNNN SDNESGGEDG YSGEDGSESE SNNGGDIDDE EFLNLLEKPK
     SKPKGRGRPS FKNNNNNNNI NNNVNLTPSK RGRGRPPKSN
 
 
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