ID   Y5897_DICDI             Reviewed;         702 AA.
AC   Q54PZ6; Q54PZ7;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 2.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Putative uncharacterized protein DDB_G0284213;
GN   ORFNames=DDB_G0284213;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL65295.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=EAL65296.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AAFI02000064; EAL65295.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AAFI02000064; EAL65296.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_638648.1; XM_633556.1.
DR   RefSeq; XP_638649.1; XM_633557.1.
DR   AlphaFoldDB; Q54PZ6; -.
DR   STRING; 44689.DDB0185896; -.
DR   PaxDb; Q54PZ6; -.
DR   PRIDE; Q54PZ6; -.
DR   EnsemblProtists; EAL65295; EAL65295; DDB_G0284213.
DR   EnsemblProtists; EAL65296; EAL65296; DDB_G0284215.
DR   GeneID; 8624478; -.
DR   GeneID; 8624479; -.
DR   KEGG; ddi:DDB_G0284213; -.
DR   KEGG; ddi:DDB_G0284215; -.
DR   dictyBase; DDB_G0284213; -.
DR   eggNOG; ENOG502RSNG; Eukaryota.
DR   InParanoid; Q54PZ6; -.
DR   Reactome; R-DDI-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   PRO; PR:Q54PZ6; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0030133; C:transport vesicle; IBA:GO_Central.
DR   GO; GO:0097422; C:tubular endosome; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0045022; P:early endosome to late endosome transport; IBA:GO_Central.
DR   Gene3D; 1.20.1050.80; -; 1.
DR   InterPro; IPR003123; VPS9.
DR   InterPro; IPR037191; VPS9_dom_sf.
DR   Pfam; PF02204; VPS9; 1.
DR   SUPFAM; SSF109993; SSF109993; 1.
DR   PROSITE; PS51205; VPS9; 1.
PE   4: Predicted;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..702
FT                   /note="Putative uncharacterized protein DDB_G0284213"
FT                   /id="PRO_0000350902"
FT   DOMAIN          337..489
FT                   /note="VPS9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00550"
FT   REGION          306..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          488..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          551..645
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   702 AA;  80287 MW;  478108F5CA9D594F CRC64;
     MDEDLNHNLF FKTIKFKFPK IFNTIESKCY TLCIPQSPSL YRMNITQKIV ESHVFIESKY
     YQSEYETLNK ESNYIIDNGY IMEKENNNKK VKIMFDELCY NKDYKSYRLI CIEEPLTGGA
     SGLNSSISRS ESDLGDLLIT QGIVKPQRPT FDQATQFFLL DSISTNINTI VFRKANQQLE
     EFERLHSINS KTDVDFFRKD LLLIHNRLMD DLVCANADFK QLHSNEKQMN SLSLILESYI
     LGKIQNKLYG DLKRLYEKEN QHLYEKMIYL SKLSFEDIGV KSDFEPHLTK AKEVIESFNT
     GINYINNNNN NNNNNNNNNN NNYNNNNNNN NNNNNNNNIN NNINNNINNI NSNNNNNNNN
     INNNNNNNNN NNNNNNNNNN NNNNEIIITP MDKLLSIVQG SREIEESIKA RAILELADED
     DILTITGDDA LPLTAYLLIH ARPKYLATDL AYCSKFILTD IFNSSYGYHL VNLIAAIDYI
     KSLDILSPTK TTTSSNNSRN TSPTSSTTNI TYGGNSESLF AQSSVNNSTI SSPKQPEDEA
     ALFNNLKKSL STMNLNPPQQ SQQQQQQQQQ QQQQQQESNF YSNNNNNNNN KTFNNSIPPH
     FISNQNSNNN NQFTSTPNLF NNNNNNTNSN NSNNNNNNNQ HNSRYSTMSF STNISNNTNI
     SNKYVKAPAV ISLDDDSDNL GDFIGKLRDM RDDEVIVSTH FK