ID   Y593_TREPA              Reviewed;         677 AA.
AC   O83602;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Uncharacterized protein TP_0593;
GN   OrderedLocusNames=TP_0593;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AE000520; AAC65571.1; -; Genomic_DNA.
DR   PIR; B71306; B71306.
DR   RefSeq; WP_010882039.1; NC_021490.2.
DR   AlphaFoldDB; O83602; -.
DR   IntAct; O83602; 7.
DR   STRING; 243276.TPANIC_0593; -.
DR   EnsemblBacteria; AAC65571; AAC65571; TP_0593.
DR   KEGG; tpa:TP_0593; -.
DR   eggNOG; COG3064; Bacteria.
DR   HOGENOM; CLU_464544_0_0_12; -.
DR   OrthoDB; 1217774at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..677
FT                   /note="Uncharacterized protein TP_0593"
FT                   /id="PRO_0000202282"
FT   TRANSMEM        80..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          523..556
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   677 AA;  75493 MW;  0583E109B453053C CRC64;
     MHDARTFFMR GSCTYAHPVA IGRFFPLSSP THTPQGTLMK SHGTMCSRNA LLLPRRGAGL
     HVLTPRIREA RPVNTGVKVI LSLFATLVLM VGVFFCAPRA SFAEFERHFY QPTVLSALST
     NLREVSKASE AWHSRYRPLF SQFCALDAVR SSFDPAQKAE DITQRAREAS ALLSSVAGLK
     GVRIVEAQKP NIHFSTFESD VLLADSGSVT YRKYNAEEHD VPLQFLGEHS PEPKVIIDEY
     HDALLYSFPS LGNYGEYRGR ILFYLSLRAL GTHLIAENKL KITDSIVPLS ADDYTFGGIV
     IGIPHEGVRS LKPSVLAEWK RKQFRVQTVR SEQHEDWALL SNASGAFVIA QAVPVLLFGF
     TPLTKGLVAM VAVVTTFLLV FQLLSLRQDP LTKLRDRLIH FHAQLLHSCL EQKESLEWEE
     VRTRLEHRRR ETDAEMKKSL PRRLRIRRGR ELDALLSKGW DDVFSTLEHG YGGARAMNRA
     QIEQLVREVL AQSLASGEAV LPVAMRADTA DEELDEVLEE LPDEAASLPS DSSPEEDLDP
     LEEVESIEGT AEESTREYAA AGDALLSKTP QLSTHSEYVP ATLAELLGRN AEPGDVVRDS
     AVLEYIEGVF DYRPCCFYES HAVHDCLEVV TGEDGPSLSP MESIVSTEDG LFTIRVSKEE
     GNHLNRDFKA LVDSVLY