Y5950_ASPFU
ID Y5950_ASPFU Reviewed; 428 AA.
AC Q4WZS3;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Putative aspergillopepsin A-like aspartic endopeptidase AFUA_2G15950;
DE EC=3.4.23.-;
DE Flags: Precursor;
GN ORFNames=AFUA_2G15950;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the peptidase A1 family. {ECO:0000305}.
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DR EMBL; AAHF01000001; EAL93892.2; -; Genomic_DNA.
DR RefSeq; XP_755930.2; XM_750837.2.
DR AlphaFoldDB; Q4WZS3; -.
DR SMR; Q4WZS3; -.
DR STRING; 746128.CADAFUBP00003100; -.
DR MEROPS; A01.079; -.
DR EnsemblFungi; EAL93892; EAL93892; AFUA_2G15950.
DR GeneID; 3513104; -.
DR KEGG; afm:AFUA_2G15950; -.
DR VEuPathDB; FungiDB:Afu2g15950; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_013253_0_1_1; -.
DR InParanoid; Q4WZS3; -.
DR OMA; GGFIFPC; -.
DR OrthoDB; 753343at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd06097; Aspergillopepsin_like; 1.
DR Gene3D; 2.40.70.10; -; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR034163; Aspergillopepsin-like_cat_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; PTHR47966; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; SSF50630; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease; Glycoprotein; Hydrolase; Protease; Reference proteome;
KW Secreted; Signal; Zymogen.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..90
FT /note="Activation peptide"
FT /evidence="ECO:0000250"
FT /id="PRO_0000390768"
FT CHAIN 91..428
FT /note="Putative aspergillopepsin A-like aspartic
FT endopeptidase AFUA_2G15950"
FT /id="PRO_0000390769"
FT DOMAIN 110..425
FT /note="Peptidase A1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01103"
FT ACT_SITE 126
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10094"
FT ACT_SITE 312
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10094"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 380
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 428 AA; 45270 MW; 8F57F74848E83B2B CRC64;
MHSLQSFLFL LLLGYGVFAA PTSPQAQSQG RSFKVERIKR GNSIHGPTAL RRAYRKFGIV
PTTFGVDLSD FVPFNTTSIS GTAANLVTDV QEPEQTGAVS AQSVQNDAAF VSPVTIGGQK
IVMNFDTGSA DFWVMNTELP ASAQVGHTVF DPSKSSTFKK MEGATFEIKY GDSSFANGGV
GTDTVDIGGA TVTGQAIGIP TSVSNSFVED TYSNGLVGLG FSSLNTVQPQ QQKTFFDNIA
DSLDKPVMTA HLKSDGVGEY EFGIIDQTKY QGDMINVTVD SSGGFWQFQS AHYKVGDGPI
QTIQNNAVAI ADTGTSLMLL DDTVVNAYYA QVKGAQYASS AGGYIYPCNT ELPNLAVAVG
AKHLATVPGT FLDFAEVGIN KTTGQTVCFG GIQSNQGTSM QILGDVFLKA FFVVFDLRGP
SIGLASPK
