CASK_HORSE
ID CASK_HORSE Reviewed; 185 AA.
AC P82187; Q8SPR0;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 30-APR-2003, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Kappa-casein;
DE Short=Kappa-CN;
DE Flags: Precursor;
GN Name=CSN3; Synonyms=CSN10;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Warmblood; TISSUE=Lactating mammary gland;
RX PubMed=12617390; DOI=10.1017/s002202990200599x;
RA Lenasi T., Rogelj I., Dovc P.;
RT "Characterization of equine cDNA sequences for alphaS1-, beta- and kappa-
RT casein.";
RL J. Dairy Res. 70:29-36(2003).
RN [2]
RP PROTEIN SEQUENCE OF 21-181.
RC TISSUE=Milk;
RX PubMed=11289269; DOI=10.1017/s0022029900004544;
RA Iametti S., Tedeschi G., Oungre E., Bonomi F.;
RT "Primary structure of kappa-casein isolated from mares' milk.";
RL J. Dairy Res. 68:53-61(2001).
CC -!- FUNCTION: Kappa-casein stabilizes micelle formation, preventing casein
CC precipitation in milk.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC -!- SIMILARITY: Belongs to the kappa-casein family. {ECO:0000305}.
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DR EMBL; AY040863; AAK83669.1; -; mRNA.
DR RefSeq; NP_001075353.1; NM_001081884.1.
DR AlphaFoldDB; P82187; -.
DR STRING; 9796.ENSECAP00000001235; -.
DR PaxDb; P82187; -.
DR Ensembl; ENSECAT00000001652; ENSECAP00000001235; ENSECAG00000001802.
DR GeneID; 100033983; -.
DR KEGG; ecb:100033983; -.
DR CTD; 1448; -.
DR VGNC; VGNC:51165; CSN3.
DR GeneTree; ENSGT00390000009184; -.
DR HOGENOM; CLU_2170214_0_0_1; -.
DR InParanoid; P82187; -.
DR OrthoDB; 1540917at2759; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000001802; Expressed in trophoblast and 1 other tissue.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0007595; P:lactation; IBA:GO_Central.
DR GO; GO:0050821; P:protein stabilization; IBA:GO_Central.
DR InterPro; IPR000117; Casein_kappa.
DR PANTHER; PTHR11470; PTHR11470; 1.
DR Pfam; PF00997; Casein_kappa; 1.
DR PIRSF; PIRSF002374; Casein_kappa; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Milk protein; Phosphoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|PubMed:11289269"
FT CHAIN 21..185
FT /note="Kappa-casein"
FT /id="PRO_0000004497"
FT SITE 117..118
FT /note="Cleavage; by chymosin/rennin"
FT /evidence="ECO:0000250"
FT MOD_RES 161
FT /note="Phosphoserine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT MOD_RES 179
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02670"
FT CARBOHYD 143
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 161
FT /note="O-linked (GalNAc...) serine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 178
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CONFLICT 29..34
FT /note="TCHKND -> RCVKNH (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 112
FT /note="C -> R (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="V -> VV (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 185 AA; 21021 MW; F7634F52CEE90606 CRC64;
MKSFFLVVNI LALTLPFLGA EVQNQEQPTC HKNDERFFDL KTVKYIPIYY VLNSSPRYEP
IYYQHRLALL INNQHMPYQY YARPAAVRPH VQIPQWQVLP NIYPSTVVRH PCPHPSFIAI
PPKKLQEITV IPKINTIATV EPTPIPTPEP TVNNAVIPDA SSEFIIASTP ETTTVPVTSP
VVQKL
