ID   Y6021_STRCO             Reviewed;         541 AA.
AC   O69851;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Exopolysaccharide phosphotransferase SCO6021;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein SCO6021;
GN   OrderedLocusNames=SCO6021; ORFNames=SC1C3.09;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; AL939126; CAA19233.1; -; Genomic_DNA.
DR   PIR; T34701; T34701.
DR   RefSeq; NP_630132.1; NC_003888.3.
DR   RefSeq; WP_011030599.1; NZ_VNID01000009.1.
DR   AlphaFoldDB; O69851; -.
DR   STRING; 100226.SCO6021; -.
DR   GeneID; 1101462; -.
DR   KEGG; sco:SCO6021; -.
DR   PATRIC; fig|100226.15.peg.6121; -.
DR   eggNOG; COG0438; Bacteria.
DR   HOGENOM; CLU_033996_0_0_11; -.
DR   InParanoid; O69851; -.
DR   OMA; DAACKNN; -.
DR   PhylomeDB; O69851; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   InterPro; IPR031357; Stealth_CR3.
DR   InterPro; IPR031356; Stealth_CR4.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
DR   Pfam; PF17102; Stealth_CR3; 1.
DR   Pfam; PF17103; Stealth_CR4; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Reference proteome; Transferase.
FT   CHAIN           1..541
FT                   /note="Exopolysaccharide phosphotransferase SCO6021"
FT                   /id="PRO_0000235961"
SQ   SEQUENCE   541 AA;  60084 MW;  46E93981DA16C6D2 CRC64;
     MTTVSDFTAH QTATAVVARK GTAGPRPSAV DAPATLTDEH GDVYVEPGLT PLAAREANRS
     ALVGLLDAAG VGHFAVRGTV DHGTVVGVAE EDRERALQAV FRGLGQYPGH LSVVDPDAPR
     PAKPVSSRDP RAWREVVGAR ILQVSWYRTD PGRHLLLGHE YGCALEFWRR QGTCLVAPRA
     NRATWAVAVG GPNVMGAARL FSRFVSDWTP GHLAPALPTR PEFLVNCADD IAFPVDAVYT
     WVDGNDPAWK QRKAQAKGEV YHAESASDAR FISRDELRYS IRSLHLFAPW IRNIYVVTDD
     QVPAWMREDL PGARIATHRE IFRNPEDLPT FNSHSIESQL HHIEGLAEHF LYFNDDMFMG
     RPVAPHSFFT PNGTARYFPS RNRIPQGAVA ETDSPVDAAC KNNRALLHER FGKVITQPME
     HIPYALRRSA MAEAELEFPE AWARTSASRF RAMTDLSPTS SFALYYAALT GRAQPGSMPF
     TYIQLAVPDL ADRLQRLLDG RDQDSFCLND AFSTPEDTEA QQELLDDFFT SYFPTPSPYE
     R