ID   Y6023_STRCO             Reviewed;         586 AA.
AC   O69853;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Exopolysaccharide phosphotransferase SCO6023;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein SCO6023;
GN   OrderedLocusNames=SCO6023; ORFNames=SC1C3.11;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; AL939126; CAA19235.1; -; Genomic_DNA.
DR   PIR; T34703; T34703.
DR   RefSeq; NP_630134.1; NC_003888.3.
DR   RefSeq; WP_011030600.1; NZ_VNID01000009.1.
DR   AlphaFoldDB; O69853; -.
DR   STRING; 100226.SCO6023; -.
DR   GeneID; 1101464; -.
DR   KEGG; sco:SCO6023; -.
DR   PATRIC; fig|100226.15.peg.6123; -.
DR   eggNOG; COG0438; Bacteria.
DR   HOGENOM; CLU_033996_0_0_11; -.
DR   InParanoid; O69853; -.
DR   OMA; PTHNSQA; -.
DR   PhylomeDB; O69853; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   InterPro; IPR031357; Stealth_CR3.
DR   InterPro; IPR031356; Stealth_CR4.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
DR   Pfam; PF17102; Stealth_CR3; 1.
DR   Pfam; PF17103; Stealth_CR4; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Reference proteome; Transferase.
FT   CHAIN           1..586
FT                   /note="Exopolysaccharide phosphotransferase SCO6023"
FT                   /id="PRO_0000235963"
SQ   SEQUENCE   586 AA;  66010 MW;  75F98F0916484116 CRC64;
     MSTGNPEASA AVGAYRSLVP AGLRRRVARR VPAGLRTVLK HLLRRLHVLS LASRLFRGFR
     ARRRWPHLFR EGERLAALAG HGDRIALVRP TVSPLGLREA NLELVVTALE EAGVDYFAVR
     GTSDFRSVLA VAESDREQVG RALERCAGHG PVYLRACRGE TPQARPALAG SRAGRQQARH
     AAVLRTGMVW SDPTGSLVLG LEHSCDIEFW KPEAGRLVAP RPNRVTQDVS PREPRVTVPV
     SRLTGFAALH TRRTRSVRTV AACADALPED VRFPIDVVYT WVDGNDPAWR RRRSAYDGGY
     HAESANAARY ISRDELRYSL RALEQNAPWV RHVHLVTDGQ RPAWLNDSHP RLTVVDHSEI
     FADPAALPTF NSHAIESRLH HIKGLSEHFL YLNDDMFLGR PVTPQDFFLS NGMTRTFFSP
     SQVPRPDPSP ADRPVDAAGK NNRRLLLENF GSVIVQKLRH APYALRRSVL EEIEREYPEA
     HWETSHSRFR SPTDISIPSS LYHYYAYFTG RAVPSDIRFA YLDLARPEVA RRLGILLARR
     DRQAFCINDT LSDGHDVDRQ TEMLATFLSA YYPVPSPFER KERAAR