CASK_OVIDA
ID CASK_OVIDA Reviewed; 124 AA.
AC Q95224;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Kappa-casein;
DE Flags: Fragment;
GN Name=CSN3; Synonyms=CSN10, CSNK;
OS Ovis dalli (Dall's sheep) (Thinhorn sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9943;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8899730; DOI=10.1006/mpev.1996.0078;
RA Cronin M.A., Stuart R., Pierson B.J., Patton J.C.;
RT "K-casein gene phylogeny of higher ruminants (Pecora, Artiodactyla).";
RL Mol. Phylogenet. Evol. 6:295-311(1996).
CC -!- FUNCTION: Kappa-casein stabilizes micelle formation, preventing casein
CC precipitation in milk.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC -!- SIMILARITY: Belongs to the kappa-casein family. {ECO:0000305}.
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DR EMBL; U37513; AAC48659.1; -; Genomic_DNA.
DR AlphaFoldDB; Q95224; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR000117; Casein_kappa.
DR PANTHER; PTHR11470; PTHR11470; 1.
DR Pfam; PF00997; Casein_kappa; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Milk protein; Phosphoprotein; Secreted.
FT CHAIN <1..124
FT /note="Kappa-casein"
FT /id="PRO_0000144117"
FT REGION 39..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 58..59
FT /note="Cleavage; by chymosin/rennin"
FT /evidence="ECO:0000250"
FT MOD_RES 80
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT MOD_RES 104
FT /note="Phosphoserine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 84
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 87
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 88
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 91
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 97
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 104
FT /note="O-linked (GalNAc...) serine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 120
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT NON_TER 1
SQ SEQUENCE 124 AA; 13379 MW; 40EF54111CF632D0 CRC64;
VALINNQFLP YPYYAKPVAV RSPAQTLQWQ VLPNTVPAKS CQDQPTTMAH HPHPHLSFMA
IPPKKDQDKT EIPAINTIAS VEPTVHSTPT TEAVVNTVDN PEASSESIAS APETNAAQVT
TTEV