CASK_PANUN
ID CASK_PANUN Reviewed; 146 AA.
AC Q29150;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Kappa-casein;
DE Flags: Fragment;
GN Name=CSN3; Synonyms=CSN10, CSNK;
OS Panthera uncia (Snow leopard) (Uncia uncia).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae;
OC Panthera.
OX NCBI_TaxID=29064;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8752004; DOI=10.1093/oxfordjournals.molbev.a025663;
RA Gatesy J., Hayashi C., Cronin M.A., Arctander P.;
RT "Evidence from milk casein genes that cetaceans are close relatives of
RT hippopotamid artiodactyls.";
RL Mol. Biol. Evol. 13:954-963(1996).
CC -!- FUNCTION: Kappa-casein stabilizes micelle formation, preventing casein
CC precipitation in milk.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC -!- SIMILARITY: Belongs to the kappa-casein family. {ECO:0000305}.
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DR EMBL; U53894; AAB08421.1; -; Genomic_DNA.
DR AlphaFoldDB; Q29150; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR000117; Casein_kappa.
DR PANTHER; PTHR11470; PTHR11470; 1.
DR Pfam; PF00997; Casein_kappa; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Milk protein; Phosphoprotein; Secreted.
FT CHAIN <1..146
FT /note="Kappa-casein"
FT /id="PRO_0000144122"
FT MOD_RES 121
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT MOD_RES 125
FT /note="Phosphoserine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT MOD_RES 143
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02670"
FT CARBOHYD 97
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 107
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 112
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 118
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 125
FT /note="O-linked (GalNAc...) serine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 142
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT NON_TER 1
SQ SEQUENCE 146 AA; 16337 MW; D667EDEF607E5E66 CRC64;
LLNQKTAKYI PVHYVLSNYP HYEPSYYPHK PAVPVNNQYM PYPYYAKPVA VRPHVQIPQW
QVLPNTYTPT VVRHPHLPAS FIVIPPKKIQ DKTGNPTINT IATAEPTLTP TTEPIVNTVV
TTEASSEFTI TSTPETTTVP VTSTMV