ID   Y612_METJA              Reviewed;         446 AA.
AC   Q58029;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Probable arogenate/prephenate dehydrogenase;
DE            EC=1.3.1.-;
GN   OrderedLocusNames=MJ0612;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SIMILARITY: In the N-terminal section; belongs to the
CC       prephenate/arogenate dehydrogenase family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98605.1; -; Genomic_DNA.
DR   PIR; D64376; D64376.
DR   RefSeq; WP_010870117.1; NC_000909.1.
DR   AlphaFoldDB; Q58029; -.
DR   SMR; Q58029; -.
DR   STRING; 243232.MJ_0612; -.
DR   EnsemblBacteria; AAB98605; AAB98605; MJ_0612.
DR   GeneID; 1451478; -.
DR   KEGG; mja:MJ_0612; -.
DR   eggNOG; arCOG00245; Archaea.
DR   HOGENOM; CLU_036672_1_0_2; -.
DR   InParanoid; Q58029; -.
DR   OMA; TDGLGKW; -.
DR   OrthoDB; 117835at2157; -.
DR   PhylomeDB; Q58029; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0070403; F:NAD+ binding; IBA:GO_Central.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IBA:GO_Central.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.30.70.380; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR005121; Fdx_antiC-bd.
DR   InterPro; IPR036690; Fdx_antiC-bd_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR008299; Prep_DH/arog_DH.
DR   InterPro; IPR003099; Prephen_DH.
DR   Pfam; PF02153; PDH; 1.
DR   PIRSF; PIRSF006549; PDH_arog_dh_reg; 1.
DR   SMART; SM00896; FDX-ACB; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF54991; SSF54991; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..446
FT                   /note="Probable arogenate/prephenate dehydrogenase"
FT                   /id="PRO_0000119199"
FT   DOMAIN          6..288
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00522"
SQ   SEQUENCE   446 AA;  50888 MW;  5968C24E2C9AC2DB CRC64;
     MKNTNLTISI IGGTDGLGKW FARYLKNKGF NVIVTGRDIE KGKNVEKELG VEFTNNNIEA
     AKKGDIVIVA VPINVTERVI KEVAPHVREG CLLMDITSIK EIPSKAMEEH VKEGVTVIPT
     HPMFGPSTPS LLRQVVILTP SEKHKNTEWF NKVYNFLKKE GAKVIVIPPE KHDRIMGIVQ
     GLTHFAFISL GATLKELNVD IKESRKFASP IYELMISIIG RIIGQNPYLY ADIQMFNPRI
     KEIHETFINQ CKEISEIVKN KDREGFVKIM KEAAKHFGSE AKRGAYYSDK AVFALTSEIE
     KLNKLIGKDV AVKNINSNVV HFGVLKDIED DYLILNKNGK EQKFNILRVE VFAGDELSKL
     KKKHLEKKYI DVSVLFKKDV DEEVILNLLK KMFDIEIIDV YEGEKIEEGY KSITFRIYGY
     NKDELKNIEK EFLKIIKNIG GKERFK