CASK_PIG
ID CASK_PIG Reviewed; 188 AA.
AC P11841;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 2.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Kappa-casein;
DE Flags: Precursor;
GN Name=CSN3; Synonyms=CSN10, CSNK;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mammary gland;
RX PubMed=1503275; DOI=10.1111/j.1365-2052.1992.tb00158.x;
RA Levine W.B., Alexander L.J., Hoganson G.E., Beattie C.W.;
RT "Cloning and sequencing of the porcine kappa-casein cDNA.";
RL Anim. Genet. 23:361-363(1992).
RN [2]
RP PROTEIN SEQUENCE OF 118-188.
RX PubMed=1001463; DOI=10.1016/0014-5793(76)80838-1;
RA Chobert J.-M., Mercier J.-C., Bahy C., Haze G.;
RT "Primary structure of the casein macropeptide of porcine and human kappa
RT caseins.";
RL FEBS Lett. 72:173-178(1976).
CC -!- FUNCTION: Kappa-casein stabilizes micelle formation, preventing casein
CC precipitation in milk.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC -!- SIMILARITY: Belongs to the kappa-casein family. {ECO:0000305}.
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DR EMBL; X51977; CAA36239.1; -; mRNA.
DR PIR; A48382; A48382.
DR RefSeq; NP_001004026.1; NM_001004026.1.
DR AlphaFoldDB; P11841; -.
DR STRING; 9823.ENSSSCP00000009882; -.
DR PaxDb; P11841; -.
DR PeptideAtlas; P11841; -.
DR Ensembl; ENSSSCT00005071630; ENSSSCP00005044683; ENSSSCG00005044514.
DR Ensembl; ENSSSCT00015052410; ENSSSCP00015020973; ENSSSCG00015039360.
DR Ensembl; ENSSSCT00030071793; ENSSSCP00030032730; ENSSSCG00030051538.
DR Ensembl; ENSSSCT00040074498; ENSSSCP00040031975; ENSSSCG00040054991.
DR Ensembl; ENSSSCT00060031916; ENSSSCP00060013673; ENSSSCG00060023533.
DR GeneID; 445511; -.
DR KEGG; ssc:445511; -.
DR CTD; 1448; -.
DR eggNOG; ENOG502TM2T; Eukaryota.
DR HOGENOM; CLU_103388_0_0_1; -.
DR InParanoid; P11841; -.
DR OrthoDB; 1540917at2759; -.
DR ChiTaRS; CSN3; pig.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR Genevisible; P11841; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0007595; P:lactation; IBA:GO_Central.
DR GO; GO:0050821; P:protein stabilization; IBA:GO_Central.
DR InterPro; IPR000117; Casein_kappa.
DR PANTHER; PTHR11470; PTHR11470; 1.
DR Pfam; PF00997; Casein_kappa; 1.
DR PIRSF; PIRSF002374; Casein_kappa; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Milk protein; Phosphoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..188
FT /note="Kappa-casein"
FT /id="PRO_0000004502"
FT SITE 117..118
FT /note="Cleavage; by chymosin/rennin"
FT /evidence="ECO:0000250"
FT MOD_RES 163
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT MOD_RES 167
FT /note="Phosphoserine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT MOD_RES 185
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02670"
FT CARBOHYD 143
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 148
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 167
FT /note="O-linked (GalNAc...) serine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02668"
FT CARBOHYD 184
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P02668"
SQ SEQUENCE 188 AA; 21122 MW; 9B41E4BE19B5D36A CRC64;
MMKSSFLIVP ILALTLPFLG AEEQNQEKLT RCESDKRLFN EEKVKYIPIY YMLNRFPSYG
FFYQHRSAVS PNRQFIPYPY YARPVVAGPH AQKPQWQDQP NVYPPTVARR PRPHASFIAI
PPKKNQDKTA IPAINSIATV EPTIVPATEP IVNAEPIVNA VVTPEASSEF LITSAPETTT
VQVTSPVV
