ID   CASK_RABIT              Reviewed;         180 AA.
AC   P33618; Q9TV51;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Kappa-casein;
DE   Flags: Precursor;
GN   Name=CSN3; Synonyms=CSN10, CSNK;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Mammary gland;
RX   PubMed=8240676; DOI=10.1677/jme.0.0110009;
RA   Bosze Z., Devinoy E., Puissant C., Fontaine M.L., Houdebine L.M.;
RT   "Characterization of rabbit kappa-casein cDNA: control of kappa-casein gene
RT   expression in vivo and in vitro.";
RL   J. Mol. Endocrinol. 11:9-17(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=New Zealand white;
RX   PubMed=8863725; DOI=10.1016/0378-1119(96)00274-0;
RA   Baranyi M., Aszodi A., Devinoy E., Fontaine M.L., Houdebine L.M., Bosze Z.;
RT   "Structure of the rabbit kappa-casein encoding gene: expression of the
RT   cloned gene in the mammary gland of transgenic mice.";
RL   Gene 174:27-34(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-180.
RC   STRAIN=New Zealand white;
RA   Hiripi L., Devinoy E., Rat P., Baranyi M., Fonatine M.L., Bosze Z.;
RT   "Polymorphism of the rabbit kappa-casein gene. Presence or absence of both
RT   1800 nt and 100 nt in two intronic regions containing microsatellites and
RT   similar to LINE.";
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 55-167.
RC   STRAIN=New Zealand white; TISSUE=Mammary gland;
RA   Dawson S.P.;
RL   Thesis (1993), Nottingham University, United Kingdom.
CC   -!- FUNCTION: Kappa-casein stabilizes micelle formation, preventing casein
CC       precipitation in milk.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the kappa-casein family. {ECO:0000305}.
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DR   EMBL; Z18243; CAA79145.1; -; mRNA.
DR   EMBL; U44057; AAC48796.1; -; Genomic_DNA.
DR   EMBL; U44055; AAC48796.1; JOINED; Genomic_DNA.
DR   EMBL; U44056; AAC48796.1; JOINED; Genomic_DNA.
DR   EMBL; AF033505; AAD48079.1; -; Genomic_DNA.
DR   EMBL; X76910; CAA54232.1; -; mRNA.
DR   PIR; JC4955; JC4955.
DR   RefSeq; NP_001076094.1; NM_001082625.3.
DR   AlphaFoldDB; P33618; -.
DR   STRING; 9986.ENSOCUP00000013028; -.
DR   Allergome; 2149; Ory c 8.
DR   PRIDE; P33618; -.
DR   Ensembl; ENSOCUT00000015158; ENSOCUP00000013028; ENSOCUG00000015167.
DR   GeneID; 100009311; -.
DR   KEGG; ocu:100009311; -.
DR   CTD; 1448; -.
DR   eggNOG; ENOG502TM2T; Eukaryota.
DR   GeneTree; ENSGT00390000009184; -.
DR   HOGENOM; CLU_103388_0_0_1; -.
DR   InParanoid; P33618; -.
DR   OMA; HPSFIAI; -.
DR   OrthoDB; 1540917at2759; -.
DR   TreeFam; TF338369; -.
DR   Proteomes; UP000001811; Chromosome 15.
DR   Bgee; ENSOCUG00000015167; Expressed in lung.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000117; Casein_kappa.
DR   PANTHER; PTHR11470; PTHR11470; 1.
DR   Pfam; PF00997; Casein_kappa; 1.
DR   PIRSF; PIRSF002374; Casein_kappa; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Milk protein; Phosphoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..180
FT                   /note="Kappa-casein"
FT                   /id="PRO_0000004503"
FT   SITE            116..117
FT                   /note="Cleavage; by chymosin/rennin"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         160
FT                   /note="Phosphoserine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P02668"
FT   CARBOHYD        132
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250|UniProtKB:P02668"
FT   CARBOHYD        142
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250|UniProtKB:P02668"
FT   CARBOHYD        147
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250|UniProtKB:P02668"
FT   CARBOHYD        153
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250|UniProtKB:P02668"
FT   CARBOHYD        160
FT                   /note="O-linked (GalNAc...) serine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P02668"
FT   CONFLICT        56..57
FT                   /note="YP -> HT (in Ref. 4; CAA54232)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        166
FT                   /note="S -> R (in Ref. 4; CAA54232)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   180 AA;  20343 MW;  A1F058E01725F56E CRC64;
     MMKHFLLVVN ILAVTLPFLA ADIQNQEQTT CRENEERLFH QVTAPYIPVH YVMNRYPQYE
     PSYYLRRQAV PTLNPFMLNP YYVKPIVFKP NVQVPHWQIL PNIHQPKVGR HSHPFFMAIL
     PNKMQDKAVT PTTNTIAAVE PTPIPTTEPV VSTEVIAEAS PELIISPETT TEATAASAAA