ID   CASK_RAT                Reviewed;         178 AA.
AC   P04468;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Kappa-casein;
DE   Flags: Precursor;
GN   Name=Csn3; Synonyms=Csn10, Csnk;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6094580; DOI=10.1016/s0021-9258(17)42688-3;
RA   Nakhasi H.L., Grantham F.H., Gullino P.M.;
RT   "Expression of kappa-casein in normal and neoplastic rat mammary gland is
RT   under the control of prolactin.";
RL   J. Biol. Chem. 259:14894-14898(1984).
CC   -!- FUNCTION: Kappa-casein stabilizes micelle formation, preventing casein
CC       precipitation in milk.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the kappa-casein family. {ECO:0000305}.
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DR   EMBL; K02598; AAA40880.1; -; mRNA.
DR   PIR; A03115; KKRT.
DR   RefSeq; NP_113750.1; NM_031562.1.
DR   AlphaFoldDB; P04468; -.
DR   STRING; 10116.ENSRNOP00000002671; -.
DR   Allergome; 2151; Rat n 8.
DR   GlyGen; P04468; 5 sites.
DR   SwissPalm; P04468; -.
DR   PaxDb; P04468; -.
DR   Ensembl; ENSRNOT00000002671; ENSRNOP00000002671; ENSRNOG00000001951.
DR   GeneID; 29188; -.
DR   KEGG; rno:29188; -.
DR   UCSC; RGD:61990; rat.
DR   CTD; 1448; -.
DR   RGD; 61990; Csn3.
DR   eggNOG; ENOG502TM2T; Eukaryota.
DR   GeneTree; ENSGT00390000009184; -.
DR   HOGENOM; CLU_103388_0_0_1; -.
DR   InParanoid; P04468; -.
DR   OMA; HPSFIAI; -.
DR   OrthoDB; 1540917at2759; -.
DR   PhylomeDB; P04468; -.
DR   TreeFam; TF338369; -.
DR   Reactome; R-RNO-5223345; Miscellaneous transport and binding events.
DR   PRO; PR:P04468; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Genevisible; P04468; RN.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0007595; P:lactation; ISO:RGD.
DR   GO; GO:0050821; P:protein stabilization; ISO:RGD.
DR   InterPro; IPR000117; Casein_kappa.
DR   PANTHER; PTHR11470; PTHR11470; 1.
DR   Pfam; PF00997; Casein_kappa; 1.
DR   PIRSF; PIRSF002374; Casein_kappa; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Milk protein; Phosphoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..178
FT                   /note="Kappa-casein"
FT                   /id="PRO_0000004504"
FT   SITE            115..116
FT                   /note="Cleavage; by chymosin/rennin"
FT   MOD_RES         120
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         145
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         159
FT                   /note="Phosphoserine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P02668"
FT   MOD_RES         165
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         175
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02670"
FT   CARBOHYD        141
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250|UniProtKB:P02668"
FT   CARBOHYD        146
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250|UniProtKB:P02668"
FT   CARBOHYD        152
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250|UniProtKB:P02668"
FT   CARBOHYD        159
FT                   /note="O-linked (GalNAc...) serine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P02668"
FT   CARBOHYD        174
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250|UniProtKB:P02668"
SQ   SEQUENCE   178 AA;  19548 MW;  0BC793AEFA8D7423 CRC64;
     MMRNFIVVMN ILALTLPFLA AEVQNPDSNC REKNEVVYDV QRVLYTPVSS VLNRNHYEPI
     YYHYRTSVPV SPYAYFPVGL KLLLLRSPAQ ILKWQPMPNF PQPVGVPHPI PNPSFLAIPT
     NEKHDNTAIP ASNTIAPIVS TPVSTTESVV NTVANTEAST VPISTPETAT VPVTSPAA