ID   Y6200_CANAL             Reviewed;         317 AA.
AC   Q5AB49; A0A1D8PDZ9; Q5AAW0;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Probable pathogenesis-related protein CaO19.6200;
DE   Flags: Precursor;
GN   OrderedLocusNames=CAALFM_C107040CA; ORFNames=CaO19.13580, CaO19.6200;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   IDENTIFICATION, AND SUBCELLULAR LOCATION.
RX   PubMed=12456000; DOI=10.1128/ec.1.4.514-525.2002;
RA   Monteoliva L., Matas M.L., Gil C., Nombela C., Pla J.;
RT   "Large-scale identification of putative exported proteins in Candida
RT   albicans by genetic selection.";
RL   Eukaryot. Cell 1:514-525(2002).
RN   [5]
RP   INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=22438810; DOI=10.1371/journal.ppat.1002592;
RA   Mayer F.L., Wilson D., Jacobsen I.D., Miramon P., Grosse K., Hube B.;
RT   "The novel Candida albicans transporter Dur31 is a multi-stage
RT   pathogenicity factor.";
RL   PLoS Pathog. 8:E1002592-E1002592(2012).
RN   [6]
RP   IDENTIFICATION, AND INDUCTION.
RX   PubMed=23136884; DOI=10.1111/mmi.12087;
RA   Rohm M., Lindemann E., Hiller E., Ermert D., Lemuth K., Trkulja D.,
RA   Sogukpinar O., Brunner H., Rupp S., Urban C.F., Sohn K.;
RT   "A family of secreted pathogenesis-related proteins in Candida albicans.";
RL   Mol. Microbiol. 87:132-151(2013).
CC   -!- FUNCTION: Secreted protein that acts as a virulence factor during
CC       infections. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- INDUCTION: Induced in hyphae and up-regulated during oral infection.
CC       Expression is higher in white cells. {ECO:0000269|PubMed:22438810,
CC       ECO:0000269|PubMed:23136884}.
CC   -!- DISRUPTION PHENOTYPE: reduces capacity to damage oral epithelial cells.
CC       {ECO:0000269|PubMed:22438810}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW26356.1; -; Genomic_DNA.
DR   RefSeq; XP_718791.1; XM_713698.1.
DR   AlphaFoldDB; Q5AB49; -.
DR   SMR; Q5AB49; -.
DR   STRING; 237561.Q5AB49; -.
DR   GeneID; 3639533; -.
DR   KEGG; cal:CAALFM_C107040CA; -.
DR   CGD; CAL0000178383; orf19.13580.
DR   VEuPathDB; FungiDB:C1_07040C_A; -.
DR   eggNOG; KOG3017; Eukaryota.
DR   HOGENOM; CLU_035730_3_1_1; -.
DR   InParanoid; Q5AB49; -.
DR   OrthoDB; 1528782at2759; -.
DR   PRO; PR:Q5AB49; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..317
FT                   /note="Probable pathogenesis-related protein CaO19.6200"
FT                   /id="PRO_0000429963"
FT   DOMAIN          187..297
FT                   /note="SCP"
FT   REGION          52..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   317 AA;  34075 MW;  651C0F982A237AD8 CRC64;
     MKFLQSFPVI LAVFSFAANL VSSKLVYEYE TKYVTVEIVT IVSGETTYTT ERLETNGPTS
     TTTTIVIPSS KPSSPESKPK SDSQPMFQSP SPVQITPSTT SINNAPSPTK PETTVTASPA
     VIAHTSVFVV TPNSAPTTSS SPPNIVQQVK AAITPSAPKP QPQPQPQENN SGTNDDSQLS
     SFSRQILEAH NIKRASHGVN PLTWSNELYN YANKVASSYD CSGNLRHTSG PYGENLALGY
     SSGANAVSAW YSEGFNFGGA GKLNHFTQVV WKSTTQLGCA YKDCRAKGWG LYIICNYQKP
     GNIIGQELAN ILPLIRS