ID   Y6206_STRCO             Reviewed;         279 AA.
AC   Q9Z596;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Putative hydroxypyruvate isomerase;
DE            EC=5.3.1.22;
GN   OrderedLocusNames=SCO6206; ORFNames=SC2G5.27c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Catalyzes the reversible isomerization between
CC       hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate
CC       semialdehyde). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate;
CC         Xref=Rhea:RHEA:11952, ChEBI:CHEBI:17180, ChEBI:CHEBI:57978;
CC         EC=5.3.1.22;
CC   -!- SIMILARITY: Belongs to the hyi family. {ECO:0000305}.
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DR   EMBL; AL939126; CAB36614.1; -; Genomic_DNA.
DR   PIR; T34860; T34860.
DR   RefSeq; NP_630309.1; NC_003888.3.
DR   RefSeq; WP_003972721.1; NZ_VNID01000009.1.
DR   AlphaFoldDB; Q9Z596; -.
DR   SMR; Q9Z596; -.
DR   STRING; 100226.SCO6206; -.
DR   PRIDE; Q9Z596; -.
DR   GeneID; 1101647; -.
DR   KEGG; sco:SCO6206; -.
DR   PATRIC; fig|100226.15.peg.6320; -.
DR   eggNOG; COG3622; Bacteria.
DR   HOGENOM; CLU_050006_1_0_11; -.
DR   InParanoid; Q9Z596; -.
DR   OMA; CEYRPRA; -.
DR   PhylomeDB; Q9Z596; -.
DR   BRENDA; 5.3.1.22; 5998.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0008903; F:hydroxypyruvate isomerase activity; IBA:GO_Central.
DR   GO; GO:0046487; P:glyoxylate metabolic process; IBA:GO_Central.
DR   InterPro; IPR026040; HyI-like.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   PIRSF; PIRSF006241; HyI; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..279
FT                   /note="Putative hydroxypyruvate isomerase"
FT                   /id="PRO_0000209112"
FT   REGION          260..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        155
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q9WYP7"
FT   ACT_SITE        256
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q9WYP7"
SQ   SEQUENCE   279 AA;  29635 MW;  18010C6C3A755D73 CRC64;
     MGFADQRFNV NLSILFTELP LLERPAAAAA AGFTAVELWW PWIDSPTPEQ SELDALKSAI
     EDAGVQLTGL NFYAGQLPGP DRGALSIPGE ESERFRANID VAADFARSLG CTALNALYGN
     RVEGVDPAEQ DRLALENLVL AARAADRIGA VLLVEALNKP ESPRYPLVSA PAAIAVVDRV
     NEATGLGNAK FLMDLYHLSM NGEDLPQVID AYAAKTGHVQ IADNPGRGAP GTGSLPLEDL
     LDRLAKAGYD GWVGLEYKPG DDPSAQSFSW LPAGARAAR