ID   Y632_CHLTR              Reviewed;         529 AA.
AC   O84637;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=UPF0159 protein CT_632;
GN   OrderedLocusNames=CT_632;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- SIMILARITY: Belongs to the UPF0159 family. {ECO:0000305}.
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DR   EMBL; AE001273; AAC68236.1; -; Genomic_DNA.
DR   PIR; D71489; D71489.
DR   RefSeq; NP_220149.1; NC_000117.1.
DR   RefSeq; WP_009872805.1; NC_000117.1.
DR   AlphaFoldDB; O84637; -.
DR   STRING; 813.O172_03460; -.
DR   PRIDE; O84637; -.
DR   EnsemblBacteria; AAC68236; AAC68236; CT_632.
DR   GeneID; 884421; -.
DR   KEGG; ctr:CT_632; -.
DR   PATRIC; fig|272561.5.peg.691; -.
DR   HOGENOM; CLU_024745_0_0_0; -.
DR   InParanoid; O84637; -.
DR   OMA; MHRHRRC; -.
DR   BioCyc; MetaCyc:MON-15766; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR   GO; GO:0070402; F:NADPH binding; IBA:GO_Central.
DR   GO; GO:0050797; F:thymidylate synthase (FAD) activity; IBA:GO_Central.
DR   GO; GO:0004799; F:thymidylate synthase activity; IBA:GO_Central.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.30.1360.170; -; 2.
DR   InterPro; IPR003669; Thymidylate_synthase_ThyX.
DR   InterPro; IPR036098; Thymidylate_synthase_ThyX_sf.
DR   PANTHER; PTHR34934; PTHR34934; 1.
DR   Pfam; PF02511; Thy1; 2.
DR   SUPFAM; SSF69796; SSF69796; 2.
DR   PROSITE; PS51331; THYX; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat.
FT   CHAIN           1..529
FT                   /note="UPF0159 protein CT_632"
FT                   /id="PRO_0000220644"
FT   DOMAIN          38..274
FT                   /note="ThyX 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00661"
FT   DOMAIN          309..511
FT                   /note="ThyX 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00661"
SQ   SEQUENCE   529 AA;  60915 MW;  35BFF03D77AD2D1E CRC64;
     MLSKEGGFSE EQRARLSHFV TNLDSPIFAL KNLPEVVKGA LFSKYSRSTL GLRALLLKEF
     LDGEGGNFLD DDQQDCELGI QKAADFYRRV LDNFGDDSVG ELGGAHLALE QVSMLAAKIL
     EDARIGGSPL EKSSRYVYFD QKVNGEYLYY RDPILMTSAF KDVFLDTCDF LFNTYSDLIP
     QVRSHFEKLY PKDPEVSQSA YTVSLRAKVL DCLRGLLPAA TLTNLGFFGN GRFWQNLLHR
     LQDNSLVEVR NIGEQSLTEL MKIIPSFVSR AESHHYHHQA MVDYRRALKE QLKSFAHRYG
     EEREISKEAG VKLVYGDPDG LYKIAAAYMF PYSEHTYAEL LDICRNIPNE DLMRILESGA
     SFRENRRHKS PRGLECAEFA FDITADFGAY RDLQRHRILT QERQLLTTKL GYTMPSQLID
     TPMEAPFREA MEKADQAYRL IAEEFPEEAQ YVVPLAYNIR WLFHINARGL QWLCELRSQP
     QGHESYRKIA IDMAREVIQF HPAYELFLKF VDYSETDLGR LQQESRKKS