Y635_MYCTU
ID Y635_MYCTU Reviewed; 158 AA.
AC P9WFK1; L0T749; P96926; Q7D9I0;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 41.
DE RecName: Full=UPF0336 protein Rv0635 {ECO:0000255|HAMAP-Rule:MF_00799};
GN OrderedLocusNames=Rv0635; ORFNames=MTCY20H10.16;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT through an interactome, reactome and genome-scale structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- INTERACTION:
CC P9WFK1; P96927: MT0665; Xeno; NbExp=5; IntAct=EBI-15655895, EBI-15655915;
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC -!- SIMILARITY: Belongs to the UPF0336 family. {ECO:0000255|HAMAP-
CC Rule:MF_00799}.
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DR EMBL; AL123456; CCP43378.1; -; Genomic_DNA.
DR PIR; H70612; H70612.
DR RefSeq; NP_215149.1; NC_000962.3.
DR RefSeq; WP_003403277.1; NZ_NVQJ01000007.1.
DR PDB; 4RLJ; X-ray; 1.75 A; A=2-158.
DR PDB; 4RLT; X-ray; 2.05 A; A=2-158.
DR PDB; 4RLU; X-ray; 2.20 A; A=2-158.
DR PDB; 4RLW; X-ray; 2.20 A; A=2-158.
DR PDBsum; 4RLJ; -.
DR PDBsum; 4RLT; -.
DR PDBsum; 4RLU; -.
DR PDBsum; 4RLW; -.
DR AlphaFoldDB; P9WFK1; -.
DR SMR; P9WFK1; -.
DR IntAct; P9WFK1; 1.
DR STRING; 83332.Rv0635; -.
DR PaxDb; P9WFK1; -.
DR DNASU; 888032; -.
DR GeneID; 45424594; -.
DR GeneID; 888032; -.
DR KEGG; mtu:Rv0635; -.
DR TubercuList; Rv0635; -.
DR eggNOG; COG2030; Bacteria.
DR OMA; VFGYQAQ; -.
DR PhylomeDB; P9WFK1; -.
DR BioCyc; MetaCyc:G185E-4777-MON; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0019171; F:3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity; IDA:MTBBASE.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR HAMAP; MF_00799; UPF0336; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR039569; MaoC-like_dehydrat_N.
DR InterPro; IPR016709; UPF0336.
DR Pfam; PF13452; MaoC_dehydrat_N; 1.
DR PIRSF; PIRSF018072; UCP018072; 1.
DR SUPFAM; SSF54637; SSF54637; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..158
FT /note="UPF0336 protein Rv0635"
FT /id="PRO_0000216143"
FT HELIX 5..7
FT /evidence="ECO:0007829|PDB:4RLJ"
FT STRAND 11..13
FT /evidence="ECO:0007829|PDB:4RLJ"
FT HELIX 22..31
FT /evidence="ECO:0007829|PDB:4RLJ"
FT HELIX 37..39
FT /evidence="ECO:0007829|PDB:4RLJ"
FT HELIX 42..46
FT /evidence="ECO:0007829|PDB:4RLJ"
FT TURN 47..49
FT /evidence="ECO:0007829|PDB:4RLJ"
FT TURN 57..60
FT /evidence="ECO:0007829|PDB:4RLJ"
FT HELIX 61..74
FT /evidence="ECO:0007829|PDB:4RLJ"
FT STRAND 77..79
FT /evidence="ECO:0007829|PDB:4RLT"
FT HELIX 81..83
FT /evidence="ECO:0007829|PDB:4RLJ"
FT STRAND 84..95
FT /evidence="ECO:0007829|PDB:4RLJ"
FT STRAND 102..115
FT /evidence="ECO:0007829|PDB:4RLJ"
FT STRAND 118..129
FT /evidence="ECO:0007829|PDB:4RLJ"
FT STRAND 134..145
FT /evidence="ECO:0007829|PDB:4RLJ"
FT STRAND 152..155
FT /evidence="ECO:0007829|PDB:4RLT"
SQ SEQUENCE 158 AA; 17481 MW; F4AD9150CE3C7326 CRC64;
MALSADIVGM HYRYPDHYEV EREKIREYAV AVQNDDAWYF EEDGAAELGY KGLLAPLTFI
CVFGYKAQAA FFKHANIATA EAQIVQVDQV LKFEKPIVAG DKLYCDVYVD SVREAHGTQI
IVTKNIVTNE EGDLVQETYT TLAGRAGEDG EGFSDGAA
