ID   Y637_ALKHC              Reviewed;         581 AA.
AC   Q9KF49;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Putative adenine deaminase BH0637;
DE            Short=Adenase;
DE            Short=Adenine aminase;
DE            EC=3.5.4.2;
GN   OrderedLocusNames=BH0637;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000305}.
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DR   EMBL; BA000004; BAB04356.1; -; Genomic_DNA.
DR   PIR; E83729; E83729.
DR   RefSeq; WP_010896813.1; NC_002570.2.
DR   AlphaFoldDB; Q9KF49; -.
DR   SMR; Q9KF49; -.
DR   STRING; 272558.10173251; -.
DR   PRIDE; Q9KF49; -.
DR   EnsemblBacteria; BAB04356; BAB04356; BAB04356.
DR   KEGG; bha:BH0637; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; IEGHFPG; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..581
FT                   /note="Putative adenine deaminase BH0637"
FT                   /id="PRO_0000142446"
SQ   SEQUENCE   581 AA;  66324 MW;  F73E228268D2C626 CRC64;
     MCEQKYRWTK KQIRQQLAVV RGEMAPTLVL KNATYLNSVR GKWLDANIWI YQDRIVYVGQ
     DMPAKLDDET EVVDCGQQVI VPGYIEHHAH PFQLYNPHSF ANYAAAMGTT TLINDNLMFF
     LALEKKKALS MIESLDELPS SMYWWCRYDP QTEMNDEEGH FLNSKIKEWL EHPLVVQGGE
     LTSWPKVITG DDGILHWMQE TRRLRKPIEG HFPGASEKTL TQMSLLGVTS DHEAMTGEEV
     IRRLDLGYMT SLRHSSIRSD LAKILREMKE LGIDDFSRCM LTTDGSPPSF YEQGIMDRLI
     KIALDEGIPP KDAYGMATYY VARYYGLDYE LGMIAPGRIA HLNFLDNVFN PVPTSVLAKG
     QWVVRDGQRY GSDSVFPWED FGMKRLTIDW DLSVDELHFS MPMGIELVNS VILKPYQVSV
     EASRDTLAED HDECFFLLLD KHGKWKIPTM IKGFAKKVSG LASSFSTTGD IILIGKCIQD
     MIVAFNALKQ QGGGIVLVEN GEVISNIPLE IMGLLSSKPM EEVMEEEKKF VKALRERGYE
     HDDPIYSLLF FSSTHLPYIR VTQRGIYDVH KKTVLFPSIM R