ID   Y6403_STRGG             Reviewed;         250 AA.
AC   B1W5S5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Putative (5-formylfuran-3-yl)methyl phosphate synthase {ECO:0000250|UniProtKB:Q58499};
DE            EC=4.2.3.153 {ECO:0000250|UniProtKB:Q58499};
DE   AltName: Full=4-(hydroxymethyl)-2-furancarboxaldehyde-phosphate synthase {ECO:0000250|UniProtKB:Q58499};
DE            Short=4-HFC-P synthase {ECO:0000250|UniProtKB:Q58499};
GN   OrderedLocusNames=SGR_6403;
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350;
RX   PubMed=18375553; DOI=10.1128/jb.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT   griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- FUNCTION: Catalyzes the formation of 4-(hydroxymethyl)-2-
CC       furancarboxaldehyde phosphate (4-HFC-P) from two molecules of
CC       glyceraldehyde-3-P (GA-3-P). {ECO:0000250|UniProtKB:Q58499}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 D-glyceraldehyde 3-phosphate = 4-(hydroxymethyl)-2-
CC         furancarboxaldehyde phosphate + 2 H2O + phosphate;
CC         Xref=Rhea:RHEA:43536, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:59776, ChEBI:CHEBI:83407; EC=4.2.3.153;
CC         Evidence={ECO:0000250|UniProtKB:Q58499};
CC   -!- SIMILARITY: Belongs to the MfnB family. {ECO:0000305}.
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DR   EMBL; AP009493; BAG23232.1; -; Genomic_DNA.
DR   RefSeq; WP_012381917.1; NC_010572.1.
DR   AlphaFoldDB; B1W5S5; -.
DR   SMR; B1W5S5; -.
DR   STRING; 455632.SGR_6403; -.
DR   EnsemblBacteria; BAG23232; BAG23232; SGR_6403.
DR   GeneID; 6209015; -.
DR   KEGG; sgr:SGR_6403; -.
DR   PATRIC; fig|455632.4.peg.6564; -.
DR   eggNOG; COG1891; Bacteria.
DR   HOGENOM; CLU_068659_0_0_11; -.
DR   OMA; NFPWVIR; -.
DR   OrthoDB; 1796491at2; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR007565; 4HFCP_synth.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF04476; 4HFCP_synth; 1.
DR   PIRSF; PIRSF015957; UCP015957; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Lyase; Schiff base.
FT   CHAIN           1..250
FT                   /note="Putative (5-formylfuran-3-yl)methyl phosphate
FT                   synthase"
FT                   /id="PRO_1000131716"
FT   ACT_SITE        29
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000250|UniProtKB:Q58499"
FT   ACT_SITE        87
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q58499"
SQ   SEQUENCE   250 AA;  25746 MW;  4277E7B68A8B0DD9 CRC64;
     MLLLISPDGV EEALACATAA EHLDIVDVKK PDEGSLGANF PWVIREIRAA VPADKPVSAT
     VGDVPYKPGT VAQAALGAAV SGATYIKVGL YGCATPDQAI DVMRGVVRAV KDFRADAFVV
     ASGYADAHRI GCVNPLALPD IARRAGADAA MLDTAIKDGT RLFDHVPPEG CAEFVRLAHE
     AGLLAALAGS VKAADLATLT RIGTDIVGVR GAVCEGGDRD AGRIQPRLVA AFRAEMDRHA
     RAFAAAPAAS