ID   Y643_PYRHO              Reviewed;         230 AA.
AC   O58377;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Uncharacterized protein PH0643;
GN   OrderedLocusNames=PH0643;
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA   Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- SIMILARITY: Belongs to the FAH family. {ECO:0000305}.
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DR   EMBL; BA000001; BAA29734.1; -; Genomic_DNA.
DR   PIR; D71109; D71109.
DR   AlphaFoldDB; O58377; -.
DR   SMR; O58377; -.
DR   STRING; 70601.3257051; -.
DR   EnsemblBacteria; BAA29734; BAA29734; BAA29734.
DR   KEGG; pho:PH0643; -.
DR   eggNOG; arCOG00235; Archaea.
DR   OMA; YALSIDM; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.850.10; -; 1.
DR   InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR   InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR   Pfam; PF01557; FAA_hydrolase; 1.
DR   SUPFAM; SSF56529; SSF56529; 1.
PE   3: Inferred from homology;
KW   Metal-binding.
FT   CHAIN           1..230
FT                   /note="Uncharacterized protein PH0643"
FT                   /id="PRO_0000156840"
FT   BINDING         74
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250"
FT   BINDING         76
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250"
FT   BINDING         105
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   230 AA;  25567 MW;  87D825BE07C0C21B CRC64;
     MNEMSSVRLP FRDGYYDVRP TKIVALAKNY AEHAREMGSE PPEEPIIFLK PPSALIGPGS
     SIILPRRSKR VDHEVELAVI MGKRAKNVPA SKAFDYILGY TIILDITARD LQAEARKKGY
     PWTISKGFDT FAPIGPRVVD SRELDPSDLE IGLKVNGKIR QLGRTSQMIF KIPELIEYIS
     HIMTLEPGDI IATGTPPGVG PLRHGDRIEA WIEGIGKMEF DVLAEDSILC