ID   Y6443_STRCO             Reviewed;         303 AA.
AC   Q9ZBH0;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase SCO6443;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=SCO6443; ORFNames=SC9B5.10;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL939127; CAA22752.1; -; Genomic_DNA.
DR   PIR; T35930; T35930.
DR   RefSeq; NP_630528.1; NC_003888.3.
DR   RefSeq; WP_011030923.1; NZ_VNID01000002.1.
DR   AlphaFoldDB; Q9ZBH0; -.
DR   SMR; Q9ZBH0; -.
DR   STRING; 100226.SCO6443; -.
DR   GeneID; 1101882; -.
DR   KEGG; sco:SCO6443; -.
DR   PATRIC; fig|100226.15.peg.6543; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_0_11; -.
DR   InParanoid; Q9ZBH0; -.
DR   OMA; NEQCAPA; -.
DR   PhylomeDB; Q9ZBH0; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..303
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase SCO6443"
FT                   /id="PRO_0000361265"
FT   BINDING         130
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         159..160
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   303 AA;  33235 MW;  3172E8EB18EDD822 CRC64;
     MADTAPLGTR TDGVEGGVGL TALLVAAARA IETHRPDALA QDIYAEHFVL GARASAHWPV
     RLDRAPGGDT SPLWGRFARY FGLRTRVLDD FLLRSVRSAG IRQVVLLGAG LDARAFRLDW
     LSDCVIFEID RDGVLAFKHR VLDTLSAEPG ARRVPIGTDL RADWAGALTA TGFDATAPTA
     WLVEGLLFYL PHAAETALID TVDRLSAPGS ALAYEVKLEK DLMAYRDSPL YVSTRRQLGI
     DLLDLFSREP RPDSAARLRD RGWTASVHTP FDFTRRHGRG PLPEENDALA GNRWVFADRA
     RPA