ID   Y644_MYCLB              Reviewed;         983 AA.
AC   B8ZUU1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=UPF0182 protein MLBr00644 {ECO:0000255|HAMAP-Rule:MF_01600};
GN   OrderedLocusNames=MLBr00644;
OS   Mycobacterium leprae (strain Br4923).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=561304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Br4923;
RX   PubMed=19881526; DOI=10.1038/ng.477;
RA   Monot M., Honore N., Garnier T., Zidane N., Sherafi D., Paniz-Mondolfi A.,
RA   Matsuoka M., Taylor G.M., Donoghue H.D., Bouwman A., Mays S., Watson C.,
RA   Lockwood D., Khamispour A., Dowlati Y., Jianping S., Rea T.H.,
RA   Vera-Cabrera L., Stefani M.M., Banu S., Macdonald M., Sapkota B.R.,
RA   Spencer J.S., Thomas J., Harshman K., Singh P., Busso P., Gattiker A.,
RA   Rougemont J., Brennan P.J., Cole S.T.;
RT   "Comparative genomic and phylogeographic analysis of Mycobacterium
RT   leprae.";
RL   Nat. Genet. 41:1282-1289(2009).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
CC   -!- SIMILARITY: Belongs to the UPF0182 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01600}.
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DR   EMBL; FM211192; CAR70738.1; -; Genomic_DNA.
DR   RefSeq; WP_010907856.1; NC_011896.1.
DR   AlphaFoldDB; B8ZUU1; -.
DR   SMR; B8ZUU1; -.
DR   EnsemblBacteria; CAR70738; CAR70738; MLBr00644.
DR   KEGG; mlb:MLBr00644; -.
DR   HOGENOM; CLU_007733_1_0_11; -.
DR   OMA; HLRYPQD; -.
DR   OrthoDB; 170146at2; -.
DR   Proteomes; UP000006900; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01600; UPF0182; 1.
DR   InterPro; IPR005372; UPF0182.
DR   PANTHER; PTHR39344; PTHR39344; 1.
DR   Pfam; PF03699; UPF0182; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..983
FT                   /note="UPF0182 protein MLBr00644"
FT                   /id="PRO_1000185784"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
SQ   SEQUENCE   983 AA;  107557 MW;  BC8AA30433CA594F CRC64;
     MGMRPAARMP KLTRRSRTLI MVALGVIVLL LAGPRLVDAY VEWLWFGELG YRSVFSTVLV
     TRVVVFLVAG LVVGGIVFAG LAVAYRTRPV FVPSHDNDPV ARYRAMALSR LRLIGVGIPA
     AIGLLAGIIA QSYWVRIQLF LHGDNFGIRD PQFGKDLGFY AFELPFYRLV LSYVFVAVFL
     AFVVNLLAHY IFGGIRLSGR TGALSRLARL QLVSLVGVLV LLKAVAYWLD RYELLSRTRS
     SKPFTGAGYT DINAVQPAKL ILIAIALICA AAVFSAITLR DFRIPAIGLV LLMLSSLIVG
     TGWPLIVEQL IAKPDAVRKE SEYIRRSITA TRHAYGLTED VVTYRNYIGD APAIAQQIAT
     DHATTSNIRL LDPTIVSPAF TQFQRGKNFY YFPDQLSIDR YLDKKGNLRD YVVAARELNP
     DRLIDNQRDW INRHTVYTHG NGFIASPANT VRGIANDPNQ NGGYPQFLVN VVGNGTVVSE
     GPARLDQPRV YFGPVISNTS ADYAIVGKNG DDREYDYETN TDTKRYTYAG SGGVPIGSWL
     SRSVFAAKFA ERNFLFSSVI GSNSKILFNR DPAQRVEAVA PWLTTDSSVY PAIVNKRLVW
     IIDGYTTLDN YPYSERTSLS SATADSTEVA FNRLAPDKRV AYIRNSVKAT VDAYDGAVTL
     YQQDEYDPVL KVWMKVFPGT VRPKGDITPE LAEHLRYPED LFKVQRMLLA KYHVNDPGTF
     FNTSDFWDVP LDPNPTASSY QPPYYIVAKN ILKNDRSASY QLTSAMNRFK QDFLAAYISA
     SSDPETYGKI TVLTIPGNVN GPKLANNAIT TDPAVSQDLG VIGRDNQNRI RWGNLLTLPV
     AQGGLLYVEP VYASPGVSDA ASSYPRLIRV AMMYNDKIGY GPTVGDALTG LFGPGAASAA
     TGIEPTEAVP PKSPAGSSTP PIAVVPSAPD GSVALSAAKA AALQEIQAVI GAAREAQKKG
     DFVAYGSALQ RLDDAITKFN STK