ID   Y644_MYCLE              Reviewed;         983 AA.
AC   Q9CCM6; O32904;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=UPF0182 protein ML0644 {ECO:0000255|HAMAP-Rule:MF_01600};
GN   OrderedLocusNames=ML0644; ORFNames=MLCB1779.46;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
CC   -!- SIMILARITY: Belongs to the UPF0182 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01600}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB11027.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL583919; CAC30153.1; -; Genomic_DNA.
DR   EMBL; Z98271; CAB11027.1; ALT_INIT; Genomic_DNA.
DR   PIR; E86989; E86989.
DR   PIR; T45332; T45332.
DR   RefSeq; NP_301532.1; NC_002677.1.
DR   RefSeq; WP_010907856.1; NC_002677.1.
DR   AlphaFoldDB; Q9CCM6; -.
DR   SMR; Q9CCM6; -.
DR   STRING; 272631.ML0644; -.
DR   EnsemblBacteria; CAC30153; CAC30153; CAC30153.
DR   KEGG; mle:ML0644; -.
DR   PATRIC; fig|272631.5.peg.1135; -.
DR   Leproma; ML0644; -.
DR   eggNOG; COG1615; Bacteria.
DR   HOGENOM; CLU_007733_1_0_11; -.
DR   OMA; HLRYPQD; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01600; UPF0182; 1.
DR   InterPro; IPR005372; UPF0182.
DR   PANTHER; PTHR39344; PTHR39344; 1.
DR   Pfam; PF03699; UPF0182; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..983
FT                   /note="UPF0182 protein ML0644"
FT                   /id="PRO_0000157725"
FT   TRANSMEM        20..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        63..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        113..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        169..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        212..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        260..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        284..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
SQ   SEQUENCE   983 AA;  107557 MW;  BC8AA30433CA594F CRC64;
     MGMRPAARMP KLTRRSRTLI MVALGVIVLL LAGPRLVDAY VEWLWFGELG YRSVFSTVLV
     TRVVVFLVAG LVVGGIVFAG LAVAYRTRPV FVPSHDNDPV ARYRAMALSR LRLIGVGIPA
     AIGLLAGIIA QSYWVRIQLF LHGDNFGIRD PQFGKDLGFY AFELPFYRLV LSYVFVAVFL
     AFVVNLLAHY IFGGIRLSGR TGALSRLARL QLVSLVGVLV LLKAVAYWLD RYELLSRTRS
     SKPFTGAGYT DINAVQPAKL ILIAIALICA AAVFSAITLR DFRIPAIGLV LLMLSSLIVG
     TGWPLIVEQL IAKPDAVRKE SEYIRRSITA TRHAYGLTED VVTYRNYIGD APAIAQQIAT
     DHATTSNIRL LDPTIVSPAF TQFQRGKNFY YFPDQLSIDR YLDKKGNLRD YVVAARELNP
     DRLIDNQRDW INRHTVYTHG NGFIASPANT VRGIANDPNQ NGGYPQFLVN VVGNGTVVSE
     GPARLDQPRV YFGPVISNTS ADYAIVGKNG DDREYDYETN TDTKRYTYAG SGGVPIGSWL
     SRSVFAAKFA ERNFLFSSVI GSNSKILFNR DPAQRVEAVA PWLTTDSSVY PAIVNKRLVW
     IIDGYTTLDN YPYSERTSLS SATADSTEVA FNRLAPDKRV AYIRNSVKAT VDAYDGAVTL
     YQQDEYDPVL KVWMKVFPGT VRPKGDITPE LAEHLRYPED LFKVQRMLLA KYHVNDPGTF
     FNTSDFWDVP LDPNPTASSY QPPYYIVAKN ILKNDRSASY QLTSAMNRFK QDFLAAYISA
     SSDPETYGKI TVLTIPGNVN GPKLANNAIT TDPAVSQDLG VIGRDNQNRI RWGNLLTLPV
     AQGGLLYVEP VYASPGVSDA ASSYPRLIRV AMMYNDKIGY GPTVGDALTG LFGPGAASAA
     TGIEPTEAVP PKSPAGSSTP PIAVVPSAPD GSVALSAAKA AALQEIQAVI GAAREAQKKG
     DFVAYGSALQ RLDDAITKFN STK