ID   Y644_TROW8              Reviewed;         958 AA.
AC   Q83NC0;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=UPF0182 protein TW644 {ECO:0000255|HAMAP-Rule:MF_01600};
GN   OrderedLocusNames=TW644;
OS   Tropheryma whipplei (strain TW08/27) (Whipple's bacillus).
OC   Bacteria; Actinobacteria; Micrococcales; Tropherymataceae; Tropheryma.
OX   NCBI_TaxID=218496;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW08/27;
RX   PubMed=12606174; DOI=10.1016/s0140-6736(03)12597-4;
RA   Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G.,
RA   Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A.,
RA   Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J.,
RA   Relman D.A.;
RT   "Sequencing and analysis of the genome of the Whipple's disease bacterium
RT   Tropheryma whipplei.";
RL   Lancet 361:637-644(2003).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
CC   -!- SIMILARITY: Belongs to the UPF0182 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01600}.
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DR   EMBL; BX251412; CAD67307.1; -; Genomic_DNA.
DR   RefSeq; WP_011096585.1; NC_004551.1.
DR   AlphaFoldDB; Q83NC0; -.
DR   SMR; Q83NC0; -.
DR   PRIDE; Q83NC0; -.
DR   GeneID; 67388425; -.
DR   KEGG; tws:TW644; -.
DR   HOGENOM; CLU_007733_1_0_11; -.
DR   OMA; HLRYPQD; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01600; UPF0182; 1.
DR   InterPro; IPR005372; UPF0182.
DR   PANTHER; PTHR39344; PTHR39344; 1.
DR   Pfam; PF03699; UPF0182; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..958
FT                   /note="UPF0182 protein TW644"
FT                   /id="PRO_0000291304"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
SQ   SEQUENCE   958 AA;  105820 MW;  95A96434DE19DEAF CRC64;
     MNIKLRFPRS SLAIAILSVV AFLVLIALTA FFLVHFYSEY LWYDQLGFTG VIVTQWAAIF
     VVFCLAFVFV SIFLWLCMFS AHKFRPRYTS LSSVLSHYQK VIDPIRKIVV LLVSLGLGAV
     AGIFAASRWD IVLAWLNKVP TGKSDPIFHN DISFYFFDLP FYRRLLFFLL VTFVLGGILS
     ILISVVYGAL RVDGKEIWLS KGARVQYAVL AAGIFVLLGL EFWLNRFDTL LSDRSGLITG
     AAYVEVNALI PGFAVLALVA LGVALLFCIT AFTSRWRLPI IGVALAVVSA LVVITALPWG
     VQRFHVDPNA RVLESEYIKR NIESTRFAYG IDKTHEVLYS AKTDVKPGQL RNDARTTASI
     RILDPGLVSR AFGQLQQFRQ YYTFGDDLSV DRYHLGGETR DAVVALRELS LSGLGSGNTW
     VNQALVYTHG YGLVAAYGND RTPDGEPKFF ESGIPTTGLL GKYEPRIYFG RKSPPYSIVG
     APSGAAPFEF DYPSSSGGES YTTFKGSGGP KLDSFLKRLI YAMKFGSEQI LLSSQVGDYS
     QILYDRDPIK RVGKVAPWLR LDRNPYPSVV DGRIVWIVDG YTTSDQFPYS DLNSFTTLSQ
     DSQSLPALVN GSDSINYIRN SVKATVDAYS GQVKLYAWDP NDPILKVWEK VFPGTLHPIK
     EISGDLMSHV RYPLELFNIQ RQILARYHVT DPGVFFSHED AWGIPIDPQK SEPVMQSTGQ
     RRSRTVFSVA QPPYYLTMRM PGQNLAAYSI YSVFIPKSTG ENSRSVLTGY LSANSDAGNI
     PGQISPDYGK LTLLRLSKDQ TVPGPGQIQN AFDSDPKVGN QLNILRQGGQ TRVLPGNLLT
     LPVGGGFLYV QPVYVQSTGS TSYTLLQKVL AAFGNKIAFE STLNQALDSL FAGNSGASNS
     GTSDISIHPP PHSDLIAQIK AALREKVDAL TNKDLVKYAQ ADSKLNELLS RYLDANRG